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Trace element levels in the liver of rats with acute and chronic fascioliasis and after treatment with zinc-copper hydroxochloride mixed crystals

Published online by Cambridge University Press:  12 April 2024

N.T. Tsocheva-Gaitandjieva ,
M.P. Gabrashanska  and
S. Tepavitcharova
N.T. Tsocheva-Gaitandjieva*
Affiliation:
Institute of Experimental Pathology and Parasitology, Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev St., Bl. 25, 1113 Sofia, Bulgaria
M.P. Gabrashanska
Affiliation:
Institute of Experimental Pathology and Parasitology, Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev St., Bl. 25, 1113 Sofia, Bulgaria
S. Tepavitcharova
Affiliation:
General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev St., Bl. 25, 1113 Sofia, Bulgaria
*
*Fax: +359 2 71 01 07 Email: [email protected]
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Abstract

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Quantities of trace elements including copper, zinc, cobalt, manganese and iron were investigated in the liver tissue of rats at the acute or chronic stages of fascioliasis following treatment with zinc-copper hydroxochloride mixed crystals. Oral dosing (with food) of zinc–copper mixed crystals to healthy rats increased zinc and copper levels in the liver and decreased the iron content compared with controls. Manganese and cobalt levels did not change significantly. Significant reductions in all trace elements except manganese occurred in the liver of rats with acute or chronic fascioliasis. Manganese levels were slightly increased in rats at the acute stage and slightly decreased in rats at the chronic stage of fascioliasis. The application of mixed zinc–copper crystals at the acute or chronic stages of fascioliasis lead to a restoration of zinc and copper levels and a slight reduction in the iron levels in liver tissue of rats. The beneficial effects of applied salts were more apparent in rats chronically infected with Fasciola hepatica.

Type
Review Article
Information
Journal of Helminthology , Volume 76 , Issue 1 , March 2002 , pp. 87 - 89
Copyright
Copyright © Cambridge University Press 2002

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