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The tissue reactions of mice to infection with Heligmosomoides polygyrus

Published online by Cambridge University Press:  05 June 2009

R. H. Cypess ,
H. L. Lucia ,
H. A. Dunsford  and
F. J. Enriquez
R. H. Cypess
Affiliation:
Department of Veterinary Microbiology, Immunology and Parasitology, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York 14850, USA
H. L. Lucia
Affiliation:
Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77550, USA
H. A. Dunsford
Affiliation:
Department of Pathology, University of Texas Health Science Center, Houston, TX 77001, USA
F. J. Enriquez
Affiliation:
Department of Veterinary Microbiology, Immunology and Parasitology, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York 14850, USA
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Abstract

The intestines of normal and resistant LAF mice were subjected to histologic study to determine the timing and mechanisms of resistance to reinfection by Heligmosomoides polygyrus. During reinfection third-stage larvae are less able to penetrate the intestinal wall.

Larvae which are able to encyst develop at a slower rate and provoke an increase in nonspecific inflammation around their cysts. After emergence from intestinal cysts, preadults are rapidly lost, but at no time were injured or destroyed larvae or adults noted.

Exsheathed larvae were injected via tail vein into control, sensitized and resistant BALB/c mice. The inflammatory response around entrapped larvae in the lung was measured at 1, 2, 4, and 8 days. A heightened inflammatory response, consisting primarily of polymorphonuclear cells with some round cells which peaked in size on day 2, was observed in both sensitized and resistant mice. A similar heightened inflammatory response was also observed in both AKR (non-resistant) BALB/c (resistant) mice vaccinated subcutaneously with exsheathed larvae.

Keywords

Heligmosmoides polygyrusmiceexsheathed larvaelung reactionhistology
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 1 , March 1988 , pp. 69 - 76
Copyright
Copyright © Cambridge University Press 1988

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