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Studies on naturally-occurring ovine fascioliasis in the Sudan

Published online by Cambridge University Press:  18 November 2009

E. M. Haroun ,
Haga A/gadir  and
A. A. Gameel
E. M. Haroun
Affiliation:
Faculty of Veterinary Science, University of Khartoum, P.O. Box 32, Khartoum North, Sudan.
Haga A/gadir
Affiliation:
Faculty of Veterinary Science, University of Khartoum, P.O. Box 32, Khartoum North, Sudan.
A. A. Gameel
Affiliation:
Faculty of Veterinary Science, University of Khartoum, P.O. Box 32, Khartoum North, Sudan.
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Abstract

Haematological, biochemical and pathological changes were investigated in 214 sheep naturally infected with Fasciola gigantica in an endemic area in the Sudan together with 82 uninfected controls. Infected animals showed a clear decrease in erythrocyte counts, haemoglobin concentration and packed cell volume, a normochromic, normocytic anaemia, leucocytosis and eosinophilia. Serum concentrations of the enzymes glutamate dehydrogenase, sorbitol dehydrogenase and glutamate oxaloacetic acid transaminase were also elevated in the infected group, indicating hepatic damage. This was confirmed by histopathological changes, which comprised degenerative and necrotic changes in hepatocytes associated with haemorrhage, fibrosis, increased lobulation of the liver, mononuclear cell infiltration with haemosiderin deposition in fluke tracks and portal areas and the formation of granulomata around fluke eggs and fluke remnants. In the infected group there was slight hyperglobulinaemia and a marked hypoalbuminaemia, with a decrease in A/G ratio. A slight rise in the level of serum bilirubin was also observed.

Keywords

Fasciola GiqanticaSheepSudanHaematology
Type
Research Papers
Information
Journal of Helminthology , Volume 60 , Issue 1 , March 1986 , pp. 47 - 53
Copyright
Copyright © Cambridge University Press 1986

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References

Dangerfield, W. G. & Finlayson, R. (1953) Estimation of Bilirubin in Serum. Journal of Clinical Pathology. 6, 173–177.CrossRefGoogle ScholarPubMed
Dargie, J. D. (1974) Fascioliasis: immunity. In: Helminth Diseases of Cattle, Sheep and Horses in Europe. Proceedings of Workshop Held at the Veterinary School of the University of Glasgow, 9–14th April, 1973, Pp. 109–113. (Urquhart, G. M. and Armour, J., Editors).Google Scholar
Dow, G.Ross, J. G. & Todd, J. R. (1968) The Histopathology of Fasciola Hepatica Infections in Sheep Parasitology. 58, 129–135.CrossRefGoogle ScholarPubMed
Ford, E. J. H. (1967)Activity of Sorbitol Dehydrogenase (SD) in the serum of sheep and cattle with liver damage. Journal of Comparative Pathology. 77, 405–41.CrossRefGoogle ScholarPubMed
Ford, E. J. H. & Boyd, J. W. (1962) Cellular damage and changes in Biliary Excretion in a liver lesion of cattle. Journal of Pathology and Bacteriology, 83, 39–48.CrossRefGoogle Scholar
Furmaga, S. & Gundlach, J. K. (1967) Studies on the serum proteins in experimental Fascioliasis of sheep. Acta Parasitologica Polonica, 15, 93–102.Google Scholar
Furmaga, S., Gundlach, J. L. & Sobieszewski, K. (1972) The behaviour of certain biochemical indicators in experimental sheep fascioliasis. Acta Parasitologica Polonica, 20, 539–550.Google Scholar
Guralp, M, Ozcan, C. & Simms, B. T. (1964) Fasciola Gigantica and Fascioliasis in Turkey. American Journal of Veterinary Research, 25, 196–210.Google Scholar
Hammond, J. A. (1973) Experimental Chronic Fasciola gigantica infection in sheep. Journal of Tropical Animal Health and Production, 5, 12–21.CrossRefGoogle Scholar
Haroun, E. M. & Hussein, M. F. (1975) Clinico-Pathological studies on Naturally-Occurring Bovine Fascioliasis in the Sudan. Journal of Helminthology, 49, 143–152.CrossRefGoogle ScholarPubMed
Kadhim, J. K. (1976) Changes in Serum Protein Values of Sheep Infected with Fasciola Gigantica. American Journal of Veterinary Research, 37, 229–231.Google ScholarPubMed
Karib, E. A. (1962) Fascioliasis in Cattle and Sheep in the Sudan. Bulletin De l'office International Des Epizooties, 58, 337–346.Google Scholar
Reid, J. F. S. (1974) Clinical Aspects and Diagnosis. In: Helminth diseases of Cattle, Sheep and Horses in Europe. Proceedings of a Workshop, held at the Veterinary School of The University of Glasgow, 9–14th April, 1973. Pp. 81–86,96–100,113–114 (Urquhart, G. M. and Armour, J, Editors).Google Scholar
Reitman, S. & Frankel, S. (1957) A Colorimetric Method for the Determination of Serum Glutamic Oxaloacetic acid and Glutamic Pyruvic transaminases. American Journal of Clinical Pathology, 28, 5–63.CrossRefGoogle Scholar
Rodkey, F. L. (1965) Direct Spectrophotometric Determination of albumin in human serum. Clinical Chemistry, 11,478–487.CrossRefGoogle ScholarPubMed
Ross, J. G., Dow, C. & Todd, J. R. (1967) A Study of Fasciola Hepatica in Sheep. Veterinary Record, 80, 543–546.CrossRefGoogle ScholarPubMed
Schalm, O. W. (1965) Veterinary Haematology, 2nd Edition. Bailliere and Cassell Ltd., London.Google Scholar
Sewell, M. M. H. (1967) Serum enzyme activities in acute ovine fascioliasis. Veterinary Record, 80, 577–578.Google Scholar
Sinclair, K. B. (1962) Observations on the clinical pathology of ovine fascioliasis. British Veterinary Journal, 118, 37–53.CrossRefGoogle Scholar
Sinclair, K. B. (1967) Physiological aspects of fascioliasis. Proceedings of the Second International Liver-Fluke Colloquium Wageningen.Google Scholar
Sinclair, K. B. (1973) The resistance of sheep to Fasciola hepatica. Studies on the development and pathogenicity of challenge infections. British Veterinary Journal, 129, 236–250.CrossRefGoogle ScholarPubMed
Sinclair, K. B. (1975) The resistance of sheep To Fasciola hepatica. Studies on the Pathophysiology of Challenge infections. Research in Veterinary Science, 19, 296–303.CrossRefGoogle ScholarPubMed
Thorpe, E. & Ford, E. J. H. (1969) Serum Enzyme and Hepatic Changes in sheep infected with Fasciola hepatica. Journal of Pathology, 97, 619–629.CrossRefGoogle ScholarPubMed
Warren, K. S., Domingo, E. O. & Cowan, R. B. T. (1967) Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity. American Journal of Pathology, 51, 735–756.Google ScholarPubMed
Weichselbaum, T. E. (1946) An accurate and rapid method for determination of proteins in small amounts of blood serum and plasma. American Journal of Clinical Pathology, 16, 40–43.CrossRefGoogle Scholar