Hostname: page-component-669899f699-qzcqf Total loading time: 0 Render date: 2025-04-27T22:16:53.106Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies on humoral immunity against Taenia taeniaeformis infection in rats

Published online by Cambridge University Press:  05 June 2009

B. H. Kwa  and
F. Y. Liew
B. H. Kwa
Affiliation:
Department of Zoology and Genetics and Cellular Biology, University of Malaya, Kuala Lumpur, Malaysia
F. Y. Liew
Affiliation:
Department of Zoology and Genetics and Cellular Biology, University of Malaya, Kuala Lumpur, Malaysia
Get access Rights & Permissions [Opens in a new window]

Abstract

Rats were infected with doses of 100, 1000, 5000 and 10 000 eggs of Taenia taeniaeformis. Haemagglutinating antibody to cysticercus antigen was detected at the 4th week of infection. The appearance and levels of antibody titre did not vary greatly with the infective dose. An IgM peak appeared at the 6th week, with IgG appearing slightly later and continuing to rise. Transfer of serum from the 1st week onwards from infections with 1000 eggs however could confer significant protection. Dilutions of hyperimmune serum (1 ml volumes) of up to 1/32 conferred significant protection on normal recipients. Hyperimmune serum transferred up to 4 days before challenge could confer 80% protection whereas serum transferred 4 days after challenge was totally non-protective. The significance of this finding is discussed in the light of current knowledge of metacestode immunity.

Type
Research Papers
Information
Journal of Helminthology , Volume 52 , Issue 2 , June 1978 , pp. 99 - 107
Copyright
Copyright © Cambridge University Press 1978

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

Campbell, D. H. (1938a) The specific protective property of serum from rats infected with Cysticercus crassicolis. Journal of Immunology, 35, 195–204.CrossRefGoogle Scholar
Campbell, D. H. (1938b) Further studies on the “non-absorbable” protective property in serum from rats infected with Cysticercus crassicolis. Journal of Immunology, 35, 465–476.CrossRefGoogle Scholar
Heath, D. D. (1973) Resistance to Taenia pisiformis larvae in rabbits – II. Temporal relationships and the development phase affected. International Journal for Parasitology, 3, 491–498.CrossRefGoogle ScholarPubMed
Heath, D. D. and Pavloff, P. (1975) The fate of Taenia taeniaeformis oncospheres in normal and passively protected rats. International Journal for Parasitology, 5, 83–88.CrossRefGoogle ScholarPubMed
Jandl, J. H. and Simmons, R. L. (1957) The agglutination and sensitisation of red cells by metallic cations: interaction between multivalent metals and the red cell membrane. British Journal of Haematology, 3, 19.CrossRefGoogle ScholarPubMed
Kraut, M. (1956) An electrophoretic study of sera from rats artificially infected with and immunised against, the larval cestode, Cysticercus fasciolaris. Journal of Parasitology, 42, 109–121.CrossRefGoogle Scholar
Kwa, B. H. and Liew, F. Y. (1975) The role of cell-mediated immunity in Taenia taeniaeformis infections. The Southeast Asian Journal of Tropical Medicine and Public Health, 6, 483–487.Google ScholarPubMed
Kwa, B. H. and Liew, F. Y. (1977) Immunity in Taeniasis-cysticercosis. I. Vaccination against with Taenia taeniaeformis in rats using purified antigen. Journal of Experimental Medicine, 146, 118–131.CrossRefGoogle ScholarPubMed
Leid, R. W. and Williams, J. F. (1974a) The immunological response of the rat to infection with T. taeniaeformis. I. Immunoglobulin classes involved in passive transfer of resistance. Immunology, 27, 195–208.Google Scholar
Leid, R. W. and Williams, J. F. (1974b) The immunological response of the rat to infection with T. taeniaeformis. II. Characterisation of reaginic antibody and allergen associated with the larval stage. Immunology, 27, 209–225.Google Scholar
Miller, H. M. Jr. (1933) Specific immune serums as inhibitors of a metazoan parasite (Cysticercus fasciolaris). Journal of Hygiene, 19, 270–277.Google Scholar
Miller, H. M. Jr. and Gardiner, M. L. (1932) Passive immunity to infection with a metazoan parasite, Cysticercus fasciolaris, in the albino rat. Journal of Preventive Medicine, 6, 479–496.Google Scholar
Miller, H. M Jr. and Gardiner, M. L. (1934) Further studies on passive immunity to a metazoan parasite, Cysticercus fasciolaris. American Journal of Hygiene, 20, 424–431.Google Scholar
Murrell, K. D. (1971) The effect of antibody on the Permeability control of larval Taenia taeniaeformis. Journal of Parasitology, 57, 875–880.CrossRefGoogle ScholarPubMed
Musoke, A. J. and Williams, J. F. (1975a) Immunoglobulins associated with passive transfer of resistance to Taenia taeniaeformis in the mouse. Immunology, 28, 97–101.Google ScholarPubMed
Musoke, A. J. and Williams, J. F. (1975b) The immunological response of the rat to infection with T. taeniaeformis. V. Sequence of appearance of protective immunoglobulins and the mechanism of action of 75δ 2a antibodies. Immunology, 29, 855–866.Google Scholar
Musoke, A. J., Williams, J. F., Leid, R. W. and Williams, C. S. F. (1975) The immunological response of the rat to infection with T. taeniaeformis. IV. Immunoglobulins involved in passive transfer of resistance from mother to offspring. Immunology, 29, 845–853.Google Scholar
Nemeth, I. (1970) Immunological study of rabbit cysticercosis. II. Transfer of immunity to Cysticercus pisiformis (Bloch, 1780) with parenterally administered immune serum or lymphoid cells. Acta Veterinaria Academiae Scientiarum Hungaricae, 20, 69–79.Google ScholarPubMed
Rickard, M. D. (1974) Hypothesis for the long-term survival of Taenia pisiformis cysticerci in rabbits. Zeitschrift für Parasitenkinde, 44, 203–209.CrossRefGoogle ScholarPubMed
Rickard, M. D. and Bell, K. J. (1971) Immunity produced against Taenia ovis and T. taeniaeformis infection in lambs and rats following in vivo growth of their larvae in filtration membrane diffusion chambers. Journal of Parasitology, 57, 571–575.CrossRefGoogle Scholar
Rickard, M. D. and Outteridge, P. M. (1974) Antibody and cell-mediated immunity in rabbits infected with the larval stages of Taenia pisiformis. Zeitschrift für Parasitenkunde, 44, 187–201.CrossRefGoogle ScholarPubMed
Varela-Diaz, V. M., Gemmell, M. A. and Williams, J. F. (1972) Taenia hydatigena and T. ovis: Antigen sharing. XII. Immunological responses of the mammalian host against tapeworm infections. Experimental Parasitology, 32, 96–101.CrossRefGoogle Scholar