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Strongyloides ratti: dissociation of immunological memory of the protection against tissue migrating larvae and intestinal adult worms in mice

Published online by Cambridge University Press:  05 June 2009

T. Abe ,
K. Yoshimura  and
Y. Nawa
T. Abe
Affiliation:
Department of Parasitology, Akita University School of Medicine, Hondo, Akita 010
K. Yoshimura
Affiliation:
Department of Parasitology, Akita University School of Medicine, Hondo, Akita 010
Y. Nawa
Affiliation:
Department of Parasitology, Miyazaki Medical College, Kiyotake, Miyazaki 889–16, Japan
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Abstract

Immunological memory generated by infection with S. ratti was studied separately in the migratory and intestinal phases in mice. Protection against reinfection in the migratory phase was 96–98% at 2 weeks but significantly decreased to 60% at 12 weeks after the primary infection. However, protection in the intestinal phase was 96% even 12 weeks after the primary infection. Recall of immunity against the intestinal phase persists for longer than that against the migratory phase in mice.

Keywords

Strongyloides rattiprotectionmemorymigratory phaseintestinal phasemiceNematodaimmunology
Type
Research Note
Information
Journal of Helminthology , Volume 67 , Issue 2 , June 1993 , pp. 161 - 164
Copyright
Copyright © Cambridge University Press 1993

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References

Abe, T., Nawa, Y. (1988a) Worm expulsion and mucosal mast cell response induced by repetitive IL-3 administration in Strongyloides ratti-infected nude mice. Immunology, 63, 181–185.Google Scholar
Abe, T. & Nawa, Y. (1988b) Kinetic study of mast-cell growth factor production by lymphocytes during the course of Strongyloides ratti infection in mice. Parasitology Research, 74, 484–488.Google Scholar
Bell, R. G., Adams, L. S. & Gerb, J. (1981) Strongyloides ratti: Dissociation of the rat's protective immunity into systemic and intestinal components. Experimental Parasitology, 52, 386–395.CrossRefGoogle ScholarPubMed
Dawkins, H. J. S. & Grove, D. I. (1981) Transfer by serum and cells of resistance to infection with Strongyloides ratti in mice. Immunology, 43, 317–322.Google Scholar
Grove, D. I. & Northern, C. (1989) Dissociation of the protective immune response in the mouse to Strongyloides ratti. Journal of Helminthology, 63, 307–314.Google Scholar
Haddow, W. J., Moqbel, R. & Wakelin, D. (1984) Transfer of immunity against Strongyloides ratti (Nematoda) using immune spleen cells. Journal of Parasitology, 70, 187–189.Google Scholar
Korenaga, M., Nawa, Y., Minori, T. & Tada, I. (1983) Strongyloides ratti: The role of enteral antigenic stimuli by adult worms in the generation of protective immunity in rats. Experimental Parasitology, 55, 358–363.Google Scholar
Nawa, Y., Abe, T., Imai, J. & Maruyama, H. (1988) Impaired natural defense of beige (Chediak-Higashi syndrome) mice against tissue-migrating larvae of Strongyloides ratti and its reconstitution by bone marrow cells. Parasite Immunology, 10, 117–126.CrossRefGoogle ScholarPubMed
Tada, I., Mimori, T. & Nakai, M. (1979) Migration route of Strongyloides ratti in albino rats. Japanese Journal of Parasitology, 28, 219–227.Google Scholar