Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-04T19:11:35.664Z Has data issue: false hasContentIssue false
  • English
  • Français

Spirometra mansonoides: effects of plerocercoid infection on glycogen deposition in rats

Published online by Cambridge University Press:  18 November 2009

C. K. Phares  and
Nguyen Duy Ai
C. K. Phares
Affiliation:
Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
Nguyen Duy Ai
Affiliation:
Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
Get access Rights & Permissions [Opens in a new window]

Abstract

The effects of infection with plerocercoids of Spirometra mansonoides on tissue glycogen deposition of rats was determined. Hypophysectomized rats infected for two days had higher liver glycogen concentrations than controls and this effect was greatest after one week. Elevated liver glycogen associated with plerocercoid infection was observed in fed animals both at the beginning and at the end of the light period as well as after an overnight fast. Glycogen phosphorylase (1,4αD glucan: orthophosphate α glucosyltransferase EC 2.4.1.1.) was inhibited but glucose-6-phosphatase (EC 3.1.3.9) was unaffected in the livers of infected hypophysectomized rats. While this effect is similar to actions of both growth hormone and insulin, plerocercoid infection had no influence on glycogen of cardiac or skeletal muscle at any time. Plerocercoid infection had no effect on the glycogen concentration of any tissue of intact rats.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 4 , December 1982 , pp. 315 - 322
Copyright
Copyright © Cambridge University Press 1982

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bergmeyer, H. & Bernt, E. (1965) Methods of Enzymatic Analysis. Bergmeyer, H. U., Editor, Academic Press, New York, p. 123.Google Scholar
Bishop, J. S. & Larner, J. (1967) Rapid activation-inactivation of liver uridine diphosphate glucoseglycogen transferase and phosphorylase by insulin and glucogon in vivo. Journal of Biological Chemistry, 242, 1354–1356.CrossRefGoogle Scholar
Bowman, R. H. (1959) Cardiac glycogen in hypophysectomized rats subjected to fatty acid feeding. American Journal of Physiology, 197, 1017–1018.CrossRefGoogle ScholarPubMed
Debodo, R. C. & Altzuler, N. A. (1958). Insulin hypersensitivity and physiological insulin antagonists. Physiology Reviews, 38, 389–445.CrossRefGoogle Scholar
Deodhar, A. D. & Mistry, S. P. (1969) Gluconeogensis in biotin deficiency: in vivo synthesis of pyruvate holocarboxylase in biotin deficient rat liver. Biochemical and Biophysical Research Communications, 34, 755–759.CrossRefGoogle Scholar
Goodman, H. & Kostyo, J. L. (1981) Altered profiles of biological activity of growth hormone fragments on adipocyte metabolism. Endocrinology, 108, 553–558.CrossRefGoogle ScholarPubMed
Harlow, D. R., Mertz, W. & Mueller, J. F. (1967) Insulin-like activity from the sparganum of Spirometra mansonoides. Journal of Parasitology, 53, 449–454.CrossRefGoogle ScholarPubMed
Illingworth, B. A. & Russell, J. A. (1951) The effects of growth hormone on glycogen in tissues of the rat. Endocrinology, 48, 423–434.CrossRefGoogle ScholarPubMed
Knobil, E. & Hotchkiss, J. (1964) Growth hormone. Annual Review of Physiology, 26, 47–74.CrossRefGoogle ScholarPubMed
Lotspeich, W. D. & Peterson, V. P. (1954) Effect of anterior pituitary growth hormone on synthesis of acetoacetate by surviving slices of rat liver. American Journal of Physiology, 176, 232–238.CrossRefGoogle ScholarPubMed
Meyer, F., Kimura, S. & Mueller, J. F. (1965) Stimulation of lipogenesis in hamsters by Spirometra mansonoides. Journal of Parasitology, 51 (suppl). 143.Google Scholar
Mueller, J. F. (1966) The laboratory propagation of Spirometra mansonoides (Mueller, 1935) as an experimental tool. VII. Improved techniques and additional notes on the biology of the cestode. Journal of Parasitology, 52, 437–443.CrossRefGoogle ScholarPubMed
Mueller, J. F. (1974) The biology of Spirometra. Journal of Parasitology, 60, 3–14.CrossRefGoogle ScholarPubMed
Newman, J. D., Armstrong, J. McD. & Bornstein, J. (1978) Effects of part sequences of human growth hormone on in vivo hepatic glycogen metabolism in the rat. Biochemica et Biophysica Acta, 544, 234–244.CrossRefGoogle ScholarPubMed
Pfleiderer, G. (1965) Methods of Enzymatic Analysis. Bergmeyer, H. U., Editor, Academic Press, New York, p. 59.CrossRefGoogle Scholar
Phares, C. K. & Carroll, R. M. (1977) A lipogenic effect in intact male hamsters infected with plerocercoids of the tapeworm Spirometra mansonoides. Journal of Parasitology, 63, 690–693.CrossRefGoogle ScholarPubMed
Phares, C. K. & Carroll, R. M. (1978) Comparison of the effects of the growth factor produced by Spirometra mansonoides and growth hormone in diabetic-hypophysectomized rats: lipid composition. Journal of Parasitology, 64, 401–405.CrossRefGoogle ScholarPubMed
Potter, V. R. & Ono, T. (1961) Enzyme patterns in rat liver and Morris hepatomas S123 during metabolic transitions. Cold Spring Harbor Symposia Quantative Biology, 26, 355–362.CrossRefGoogle Scholar
Porterfield, S. P. (1979) The effects of growth hormone, thyroxine and insulin on the activities of reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, glucose-6-phosphatase and glycogen phosphorylase in fetal rat liver. Hormone Metabolic Research, 11, 444–448.CrossRefGoogle ScholarPubMed
Randle, P. J., Newsholme, E. A. & Garland, P. B. (1964) Regulation of glucose uptake by muscle. Biochemical Journal, 93, 652–665.CrossRefGoogle ScholarPubMed
Ruegamer, W. R. & Mueller, J. F. (1973) Responses in hypophysectomized rats implanted with plerocercoids of the tapeworm. Spirometra mansonoides. Proceedings of the Society for Experimental Biology and Medicine, 143, 133–137.CrossRefGoogle ScholarPubMed
Russell, J. A. & Bloom, W. L. (1956) Hormonal control of glycogen in the heart and other tissues in rats. Endocrinology, 58, 83–94.CrossRefGoogle ScholarPubMed
Sadun, E. H., Williams, J. S., Meroney, F. C. & Mueller, J. F. (1965) Biochemical changes in mice infected with spargana of the cestode Spirometra mansonoides. Journal of Parasitology, 51, 532–534.CrossRefGoogle ScholarPubMed
Sillero, M. A. G. (1969) Enzyme involved in fructose metabolism in liver and glyceraldehyde metabolic crossroad. European Journal of Biochemistry, 10, 345.CrossRefGoogle Scholar
Steelman, S. L., Glitzer, M. S., Ostlind, D. A. & Mueller, J. F. (1971) Biological properites of the growth hormonelike factor from the plerocercoid of Spirometra mansonoides. Recent Progress in Hormone Research, 27, 97–120.Google Scholar
Sutherland, E. W. (1955) In: Methods in Enzymology, Colowick, S. P. & Kaplan, N. O., Editors, Academic Press, New York, 1, 215–222.CrossRefGoogle Scholar