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Shedding of Angiostrongylus costaricensis larvae in the faeces of Swiss mice experimentally infected with different infective doses

Published online by Cambridge University Press:  24 October 2018

C.C. Hermes ,
E. Benvegnú ,
M.M. Costa ,
R. Rodriguez  and
M.I.B. Vieira Open the ORCID record for M.I.B. Vieira [Opens in a new window]
C.C. Hermes
Affiliation:
Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Campus I, BR 285, Bairro São José. 99052-900 – Passo Fundo, Rio Grande do Sul, Brazil
E. Benvegnú
Affiliation:
Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Campus I, BR 285, Bairro São José. 99052-900 – Passo Fundo, Rio Grande do Sul, Brazil
M.M. Costa
Affiliation:
Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Campus I, BR 285, Bairro São José. 99052-900 – Passo Fundo, Rio Grande do Sul, Brazil
R. Rodriguez
Affiliation:
Faculdade de Medicina, Universidade de Passo Fundo – UPF; Instituto de Patologia de Passo Fundo, Rio Grande do Sul, Brazil
M.I.B. Vieira*
Affiliation:
Programa de Pós-graduação em Bioexperimentação, Universidade de Passo Fundo - UPF, Campus I, BR 285, Bairro São José. 99052-900 – Passo Fundo, Rio Grande do Sul, Brazil
*
Author for correspondence: M.I.B. Vieira, E-mail: [email protected]
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Abstract

Abdominal angiostrongyliasis is an endemic zoonosis in southern Brazil caused by the nematode Angiostrongylus costaricensis, which uses terrestrial molluscs as intermediate hosts and wild rodents as final hosts. Humans can be infected by ingesting infectious A. costaricensis larvae. To date, correlations between shedding of first-stage larvae (L1) and different infective doses of third-stage larvae (L3) have not been elucidated. The aim of this study was to assess L1 faecal shedding levels in Swiss mice experimentally infected with different doses of A. costaricensis L3 and to determine whether infective doses are related to mortality. Thirty-two male Swiss mice were divided evenly into a non-infected control (NI-Con); low-dose infection (LD-Inf); medium-dose infection (MD-Inf) and high-dose infection (HD-Inf) groups infected with 0, 5, 15 and 30 A. costaricensis L3, respectively. Faecal samples were collected from each animal, starting at day 20 post infection. HD-Inf mice had greater faecal L1 shedding levels than LD-Inf mice, but not a significantly shortened survival. In conclusion, infective doses of A. costaricensis L3 affect L1 shedding levels without altering mortality in Swiss mice.

Keywords

abdominal angiostrongyliasisfaecal shedding of larvaeinfective doses
Type
Research Paper
Information
Journal of Helminthology , Volume 94 , 2020 , e3
Copyright
Copyright © Cambridge University Press 2018 

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