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Schistosoma mansoni: the survival and reproductive status of mature infections in mice treated with oxamniquine

Published online by Cambridge University Press:  18 November 2009

Irene Popiel  and
David A. Erasmus
Irene Popiel
Affiliation:
Department of Zoology, University College, Cardiff, Wales, UK
David A. Erasmus
Affiliation:
Department of Zoology, University College, Cardiff, Wales, UK
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Abstract

A single oral dose of 50 mg/kg of oxamniquine administered to mice with mature infections of Schistosoma mansoni gave rise to a hepatic shift and almost total elimination of the male worms. Regression of the reproductive system and a conspicuous reduction in size took place in the residual females which eventually resembled sexually immature adults. A second dose of oxamniquine had no apparent effect on these females within a period of 28 days following this treatment and it is suggested that this change in reproductive status is the result of discontinued male stimulation.

Type
Research Note
Information
Journal of Helminthology , Volume 56 , Issue 3 , September 1982 , pp. 257 - 261
Copyright
Copyright © Cambridge University Press 1982

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References

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