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Schistosoma japonicum and S. mansoni: comparison of larval migration patterns in mice

Published online by Cambridge University Press:  05 June 2009

M. Gui ,
J.R. Kusel ,
Y.E. Shi  and
A. Ruppel
M. Gui
Affiliation:
Institute of Tropical Hygiene, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany Depertment of Parasitology, Tongji Medical University, 430030 Wuhan, People's Republic of China
J.R. Kusel
Affiliation:
Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, UK
Y.E. Shi
Affiliation:
Depertment of Parasitology, Tongji Medical University, 430030 Wuhan, People's Republic of China
A. Ruppel*
Affiliation:
Institute of Tropical Hygiene, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
*
*Author for the correspondence.
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Abstract

Mice were infected percutaneously with cercariae of Schistosoma japonicum or S. mansoni and parasites recovered by tissue-mincing from the skin or lungs or by perfusion of the mesenteric veins. S. japonicum had a narrow peak of recovery (up to 30%) from the lungs 3 days after infection, whereas lung recovery of S. mansoni peaked only on day 6 and levelled off during the following week. Infection with S. japonicum induced lung petechiae, but only after most of the parasites had left the lungs. The axillary lymph nodes draining the infection site increased in weight after infection and this effect was much greater and longer with S. mansoni than with S. japonicum. S. japonicum was perfusable from the mesenteric veins earlier (from day 3 onwards) and in higher number (40–60% from days 6 to 10) than S. mansoni (20% on day 20). The percentage of cercariae developing to adult worms was 57% for S. japonicum and 33% for S. mansoni. The data demonstrate that S. japonicum might escape from local tissue reactions in the skin and lungs and, due to its rapid migration, might induce only poor lymphocyte proliferation. As a possible consequence, S. japonicum may establish more efficiently in mice than S. mansoni.

Type
Research Papers
Information
Journal of Helminthology , Volume 69 , Issue 1 , March 1995 , pp. 19 - 25
Copyright
Copyright © Cambridge University Press 1995

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References

Clegg, J.A. (1965) In vitro cultivation of Schistosoina mansoni. Experimental Parasitology 16, 133–147.CrossRefGoogle ScholarPubMed
Constant, S.L. & Wilson, R.A. (1992) In vivo lymphocyte responses in the draining lymph nodes of mice exposed to Schistosoma mansoni: Preferential proliferation of T cells is central to the induction of protective immunity. Cellular Immunology 139, 145–161.CrossRefGoogle Scholar
Constant, S.L., Mountford, A.P. & Wilson, R.A. (1990) Phenotypic analysis of the cellular responses in regional lymphoid organs of mice vaccinated against Schistosoma mansoni. Parasitology 101, 15–23.CrossRefGoogle ScholarPubMed
Crabtree, J.E. & Wilson, R.A. (1986) The role of pulmonary cellular reactions in the resistance of vaccinated mice to Schistosoma mansoni. Parasite Immunology 8, 265–285.CrossRefGoogle ScholarPubMed
Dean, D.A. & Mangold, B.L. (1992) Evidence that both normal and immune elimination of Schistosoma mansoni take place at the lung stage of migration prior to parasite death. American Journal of Tropical Medicine and Hygiene 47, 238–248.CrossRefGoogle Scholar
Fan, P.C. & Lin, L.L. (1994) Encapsulated egg deposition pattern of Schistosoma japonicum in the peritoneal cavity of mice. Journal of Helminthology 68, 125–129.CrossRefGoogle ScholarPubMed
Georgi, J.R., Dean, D.A. & Mangold, B.L. (1983) Schistosoma mansoni: temporal distribution of radioselenium-labelled schistosomula in lungs of mice during the first two weeks of infection. Parasitology 86, 31–36.CrossRefGoogle ScholarPubMed
Georgi, J.R., Wade, S.E. & Dean, D.A. (1986) Attrition and temporal distribution of Schistosoma mansoni and S. haematobium schistosomula in laboratory mice. Parasitology 93, 55–70.CrossRefGoogle ScholarPubMed
Gui, M., Wales, A., Jones, J.T., Kusel, J.R., Numrich, P., Shi, Y.E. & Ruppel, A. (1993) Vaccination of mice with radiation attenuated cercariae of Schistosoma japonicum or S. mansoni. Mitteilungen der Österreichischen Gesellschaft für Tropenmedizin und Parasitologie 15, 43–50.Google Scholar
He, Y.X., Hu, Y.Q., Yu, Q.F. & Tang, Z.J. (1991) Characteristics of different isolates of Schistosoma japonicum from China in the final hosts. Southeast Asian Journal of Tropical Medicine and Public Health 22, 240–244.Google ScholarPubMed
He, Y.X., Yu, Q.F., Yu, P., Mao, C.S. & Hu, Y.Q. (1990) Penetration of Schistosoma japonicum cercariae into host skin. Chinese Medical Journal 103, 34–44.Google ScholarPubMed
Laxer, M.J. & Tuazon, C.U. (1992) Migration of 75Semethionine-labeled Schistosoma japonicum in normal and immunized mice. Journal of Infectious Diseases 166, 1133– 1138.CrossRefGoogle ScholarPubMed
Miller, P. & Wilson, R.A. (1978) Migration of the schistosomula of Schistosoma mansoni from skin to lungs. Parasitology 77, 281–302.CrossRefGoogle ScholarPubMed
Mitchell, G.F., Tiu, W.U. & Garcia, E.G. (1991) Infection characteristics of Schistosoma japonicum in mice and relevance to the assessment of schistosome vaccines. Advances in Parasitology 30, 167–200.CrossRefGoogle Scholar
Moll, H., Fuchs, H., Blank, C. & Röllinghoff, M. (1993) Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells. European Journal of Immunology 33, 1595–1601.CrossRefGoogle Scholar
Moloney, N.A. & Webbe, G. (1983) The host-parasite relationship of Schistosoma japonicum in mice. Parasitology 87, 327–342.CrossRefGoogle Scholar
Moloney, N.A., Hinchcliffe, P. & Webbe, G. (1985) The simple laboratory maintenance of a highly productive Schistosoina japonicum life cycle. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 67–68.CrossRefGoogle Scholar
Mountford, A.P., Coulson, P.S. & Wilson, R.A. (1988) Antigen localization and the induction of resistance in mice vaccinated with irradiated cercariae of Schistosoma mansoni. Parasitology 97, 11–25.CrossRefGoogle ScholarPubMed
Olivier, L. (1952) A comparison of infections in mice with three species of schistosomes, Schistosoma mansoni, Schistosoma japonicum, and Schistosomatium douthitti. American Journal of Hygiene 55, 22–35.Google ScholarPubMed
Rubinstein, D., Roska, A.K. & Lipsky, P.E. (1986) Liver sinusoidal lining cells express class II histocompatibility antigens but are poor stimulators of fresh allogeneic T lymphocytes. Journal of Immunology 137, 1803–1810.CrossRefGoogle ScholarPubMed
Ruppel, A., Shi, Y.E. & Moloney, N.A. (1990) Schistosoma mansoni and S. japonicum: comparison of levels of ultraviolet irradiation for vaccination of mice with cercariae. Parasitology 101, 23–26.CrossRefGoogle ScholarPubMed
Sher, A., Mackenzie, P. & Smithers, S.R. (1974) Decreased recovery of invading parasites from the lungs as a parameter of acquired immunity to schistosomiasis in the mouse. Journal of Infectious Diseases 130, 626–633.CrossRefGoogle ScholarPubMed
Smith, M.A., Clegg, J.A., Kusel, J.R. & Webbe, G. (1975) Lung inflammation in immunity of Schistosoma mansoni. Experientia 31, 595–596.CrossRefGoogle ScholarPubMed
Smithers, S.R. & Gammage, K. (1980) Recovery of Schistosoma mansoni from the skin, lungs and hepatic portal system of naive mice and mice previously exposed to S. mansoni: evidence for two phases of parasite attrition in immune mice. Parasitology 80, 289–300CrossRefGoogle Scholar
Smithers, S.R. & Terry, R.J. (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Usawattanakul, W., Kamijo, T. & Kojima, S. (1982) Comparison of recovery of schistosomula of Schistosoina japonicum fmm lungs of mice and rats. Journal of Parasitology 68, 783–790,CrossRefGoogle Scholar
Wheater, P.R. & Wilson, R.A. (1979) Schistosoma mansoni: a histological study of migration in the laboratory mouse. Parasitology 79, 49–62.CrossRefGoogle ScholarPubMed
Wilson, R.A. & Coulson, P.S. (1986) Schistosoma mansoni: dynamics of migration through the vascular system of the mouse. Parasitology 92, 83–100.CrossRefGoogle ScholarPubMed