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Pathophysiology of Mesocestoides corti infection in the mouse

Published online by Cambridge University Press:  18 November 2009

T. R. White ,
R. C. A. Thompson ,
W. J. Penhale ,
D. A. Pass  and
J. N. Mills
T. R. White
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
R. C. A. Thompson
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
W. J. Penhale
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
D. A. Pass
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
J. N. Mills
Affiliation:
Applied Veterinary Medicine, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
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Abstract

Liver histology and serum enzyme and protein changes were studied in two strains of mice showing different initial susceptibilities to infection with Mesocestoides corti. The results show an increase in ALT and AST levels during the period of invasion and proliferation in the liver and a decrease in the levels of these two enzymes following encapsulation of the parasite in the liver and liver regeneration. A progressive loss of albumin was accompanied by increases in the levels of the beta- and gamma-globulins. These changes are discussed in the light of our knowledge of the effects of this parasite upon its host.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 2 , June 1982 , pp. 145 - 154
Copyright
Copyright © Cambridge University Press 1982

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