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The pathogenesis of benzimidazole-resistant and benizimidazole-susceptible strains of trichostrongylus colubriformis in the Mongolian gerbil (Meriones unguiculatus)

Published online by Cambridge University Press:  05 June 2009

John M. Maclean ,
David lewis  and
Peter H. Holmes
John M. Maclean
Affiliation:
Department of Veterinary Physiology, University of Glasgow Veterinary School, Bearsden Road, Glasgow, Scotland, U.K.
David lewis
Affiliation:
Pfizer Central Research, Sandwich, Kent, England, U.K.
Peter H. Holmes
Affiliation:
Department of Veterinary Physiology, University of Glasgow Veterinary School, Bearsden Road, Glasgow, Scotland, U.K.
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Abstract

Mongolian gerbils were infected with either a benzimidazole-susceptible or a benzimidazole-resistant strain of Trichostrongylus colubriformis larvae. The comparative pathogensis of both strains of T. colubriformis was investigated for 50 days post-infection. The gerbils infected with the drug-susceptible strain of the parasite showed lower survival rates, reduced body weights, higher parasite egg output and higher worm burdens than animals intected with the drug-resistant stram of parasite. There was also evidence of an enhanced hypoalbuminaemia and a more marked gastrointestinal plasma leak in the gerbils infected with the drug-susceptible strain of patasite. Scanning electron microscope examination of the small intestine showed signs of villus atriphy in both groups of ingected grebils.

Keywords

PathogenesisTrichostrongylus colubriformisMeriones unguiculatusbenzimidazole resistance
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 2 , June 1987 , pp. 179 - 189
Copyright
Copyright © Cambridge University Press 1987

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