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Nonspecific immunomodulation influences resistance of mice to experimental infection with Mesocestoides corti and Ascaris suum

Published online by Cambridge University Press:  05 June 2009

J. Heřmánek
J. Heřmánek
Affiliation:
Institute of Parasitology, Czechoslovak Academy of Sciences, Branišovská 31, 37005 České Budějovice, Czechoslovakia
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Abstract

The influence of nonspecific immunomodulation on the course of experimental infection was examined in larval cestodosis (Mesocestoides corti) and ascaridosis (Ascaris suum) in mice. Immunosuppressive treatment (with azathioprine or hydrocortisone) resulted in a decrease of resistance in both models. The subsequent administration of T-activin to immunosuppressed mice led to the restoration of resistance to a level equal to that of untreated control mice. The administration of different immunomodulators partially protected mice against M. corti (T-activin. thymomodulin) or A. suum (T-activin. thymomodulin. thymosin fr.5. bursa-activin) infection. The protective effect of different treatments did not correlate with the level of specific antibody in the sera of infected mice. These results, which confirmed the decisive role of T-cell immunity in the resistance to the helminth infections, raise the possibility of the use of immunomodulators (thymic preparations) in the immunoprophylaxis of helminthoses.

Keywords

Ascaris suumMesocestoides cortiresistanceimmunomodulationhydrocortisoneazathioprineNematodaCestoda
Type
Research Papers
Information
Journal of Helminthology , Volume 65 , Issue 2 , June 1991 , pp. 121 - 132
Copyright
Copyright © Cambridge University Press 1991

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