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Macrophage-mediated damage to filarial worms (Dipetalonema setariosum) in vivo

Published online by Cambridge University Press:  18 November 2009

M. J. Worms  and
Diane J. McLaren
M. J. Worms
Affiliation:
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Diane J. McLaren
Affiliation:
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
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Abstract

An adult female Dipetalonema setariosum (Mönnig 1926) recovered from the pleural cavity of Meriones libycus and bearing an adherent cell mass was examined by means of electron microscopy. The host reaction consisted exclusively of macrophages and was associated with disruption of the cuticular membrane and invasion of the cuticle itself. There was no evidence of prior activity by other cell types. Initiation of damage appeared to be associated with the release of lysosomal enzymes by the macrophages. Within the reaction a localized breaching of the cuticle had occurred and cells had penetrated the internal tissues of the worm. It is suggested that macrophages may play a role in the elimination of effete worms from an established population.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 3 , September 1982 , pp. 235 - 241
Copyright
Copyright © Cambridge University Press 1982

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References

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