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Investigations of transfer factor activity in resistance to Trichostrongylus colubriformis infections in guinea-pigs

Published online by Cambridge University Press:  18 November 2009

J. G. Ross  and
W. G. Halliday
J. G. Ross
Affiliation:
Veterinary Laboratory, Eskgrove, Lasswade, Midlothian EH18 1HU, Scotland
W. G. Halliday
Affiliation:
Veterinary Laboratory, Eskgrove, Lasswade, Midlothian EH18 1HU, Scotland
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Abstract

Resistance to challenge infection with Trichostrongylus colubriformis was studied in an outbred strain of guinea-pigs. Resistance was conferred by previous infections of 50 or 100 infective larvae and by intraperitoneal, intramuscular and subcutaneous administration of dialysed transfer factor prepared from guinea-pigs infected with T. colubriformis, by intraperitoneal administration of transfer factor prepared from the blood of sheep infected with T. colubriformis and on one of three occasions using transfer factor prepared from guinea-pigs which had not been infected with T. colubriformis. No significant resistance was transferred by administration of antigen prepared from adult T. colubriformis, or by non-dialysed transfer factor, or by dialysed transfer factor prepared from T. colubriformis-infected guinea-pig tissue which had been stored for several months at −20°C.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 1 , March 1982 , pp. 27 - 35
Copyright
Copyright © Cambridge University Press 1982

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