Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-04T17:59:41.846Z Has data issue: false hasContentIssue false
  • English
  • Français

Intestinal absorption of glucose in rats after continuous challenge with larvae of Nippostrongylus brasiliensis

Published online by Cambridge University Press:  05 June 2009

Kausar J. Cheema  and
A. M. Scofield
Get access Rights & Permissions [Opens in a new window]

Abstract

The rate of glucose absorption and metabolism and the associated fluid transfer of the small intestine of rats was measured in vitro using an everted sac technique after daily doses of 0, 5, 25 or 225 infective larvae of Nippostrongylus for periods of one to five weeks. Though there were occasional significant changes in the physiology of the intestine there were no obvious patterns or trends with respect to time at any infection level. This differs from the response after a single infection. The possible role of immune adaptation and reduced immunogenicity of the worms during repeated infections is considered.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 3 , September 1984 , pp. 263 - 266
Copyright
Copyright © Cambridge University Press 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCE

Castro, G.A.Olson, L.J. & Baker, R.D. (1967) Glucose malabsorption and intestinal histopathology in Trichinelta spiralis—infected guinea-pigs. Journal of Parasitology, 53, 595–612.CrossRefGoogle ScholarPubMed
Coop, R.L. & Angus, K.W. (1973) The effect of continuous doses of Trichostrongylus colubriformls larvae on scrum electrolytes and intestinal enzyme activity in sheep. Parasitology, 67, p. v.Google Scholar
Coop, R.L. & Angus, K.W. (1975) Tlic effect of continuous doses of Trkhoslrongylus colubriformls larvae on the intestinal mucosa of sheep and on liver vitamin A concentration. Parasitology, 70, 1–9.CrossRefGoogle Scholar
Coop, R.L., ANGUS, K.W. & Sykes, A.R. (1979) Chronic infection with Trichostrongylus vilrinus in sheep. Pathological changes in the small intestine. Research in Veterinary Science, 27, 363–371.CrossRefGoogle Scholar
Jenkins, D.C. & Phillipson, R.F. (1971) The kinetics of repeated low-lcvcl infections of Nippostrongylus brasiliensis in the laboratory rat. Parasitology, 62, 457–465.CrossRefGoogle ScholarPubMed
Jenkins, D.C. & Phillipson, R.F. (1972) Increased establishment and longevity of Nippostrongylus brasiliensis in immune rats given repeated small infections. InternationalJournalfor Parasitology, 2, 105–111.Google ScholarPubMed
Morley, G., Dawson, A. & Marks, V. (1968) Manual and autoanalyscr methods for measuring blood glucose using guaiacum and glucose oxidasc. Proceedings of the Association of Clinical Biochemists, 5, 42–45.CrossRefGoogle Scholar
Nolla, H., Bristol, J.R. & Mayberry, L.F. (1982) In vivo water flux and glucose absorption in the small intestine of Nippostrongylus brasilicnsls(Ncmaloda) infected rats. Molecular and biochemical Parasitology, Supplement, 396–397.Google Scholar
Phillipson, R.F. & Jenkins, D.C. (1970) Percentage development of a second infection of Nippostrongylus brasiliensis in rats. Zeitschrift fur Parasitenkunde, 33, 355–357.CrossRefGoogle ScholarPubMed
Scofield, A.M. (1974) Intestinal absorption of D-glucosc and D-galactosc in rats infected with Nematospiroides dubius. Comparative Biochemistry and Physiology, 47A, 219–231.CrossRefGoogle Scholar
Scofield, A.M. (1977) Intestinal absorption of hexoscs in rats infected with Nippostrongylus brasiliensis. International Journal for Parasitology, 7, 159–165.CrossRefGoogle ScholarPubMed
Scofield, A.M. (1980) Effect of level of infection with Nippostrongylus brasiliensis on intestinal absorption of hexoscs in rats. International Journal for Parasitology, 10, 375–380.CrossRefGoogle ScholarPubMed
Symons, L.E.A. (1960) Pathology of infestation of the rat with Nippostrongylus muris (Yokogawa). IV. The absorption of glucose and histidinc. Australian Journal of Biological Sciences, 13, 180–187.CrossRefGoogle Scholar
Wilson, P.A.G. & Dick, J.M. (1964) Culture and isolation of Nippostrongylus brasiliensis infective larvae for biochemical studies. Journal of Ilelminthology, 38, 399–404.CrossRefGoogle ScholarPubMed