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Induction of ulcerative colitis in mice influences the course of infection with the nematode Trichuris muris

Published online by Cambridge University Press:  09 July 2014

M.C. Vegas-Sánchez ,
E. Rollán-Landeras ,
J.J. García-Rodríguez  and
F. Bolás-Fernández
M.C. Vegas-Sánchez
Affiliation:
IDCsalud-Fundación Jiménez Díaz, Avda Reyes Católicos, 2, 28040Madrid, Spain
E. Rollán-Landeras
Affiliation:
Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad Complutense, 28040Madrid, Spain
J.J. García-Rodríguez
Affiliation:
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040Madrid, Spain
F. Bolás-Fernández*
Affiliation:
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040Madrid, Spain
*
*E-mail: [email protected]
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Abstract

The aim of this study was to assess the effect of infection with the nematode whipworm Trichuris muris on the course of chemically induced acute ulcerative colitis in CBA/J mice, a strain proven to be highly resistant to infection with T. muris. Each mouse was infected with 50 embryonated eggs of T. muris by oral gavage. Acute colitis was triggered by administering 4% dextran sulphate sodium (DSS) in the drinking water for nine consecutive days at different times after infection. Concurrent infection and DSS administration exacerbate the severity of the colitis while favouring the permanence of parasites in the intestine. The induction of ulcerative colitis from days 54 to 62 post-infection (p.i.), when all worms had been expelled, ameliorated the course of the inflammatory disease. When ulcerative colitis was triggered earlier on, from days 27 to 35 p.i., the beneficial effects on inflammatory events were clearly shown with signs of mucosal epithelization and regeneration as early as day 1 after DSS administration. Previous infections by T. muris therefore accelerate recovery from subsequently induced inflammatory bowel disease and such an effect assists the nematode to persist in the intestinal niche.

Type
Research Papers
Information
Journal of Helminthology , Volume 89 , Issue 5 , September 2015 , pp. 593 - 600
Copyright
Copyright © Cambridge University Press 2014 

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