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Immunological Studies on Experimental Infection of Pigs with Ascaris suum Goeze, 1782 I. An Introduction with a Review of the Literature and the Demonstration of Complement-fixing Antibodies in the Serum*

Published online by Cambridge University Press:  05 June 2009

L. F. Taffs
L. F. Taffs
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Cambridge
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Extract

1. An introduction to a study of immunity against A. suum in the pig is given. A review of the literature on the life cycle, a note on terminology and a general discussion on immunity to helminths has also been included.

2. By first removing the procomplementary activity of pig serum to guineapig complement with hydrochloric acid, it was possible to apply the complement fixation test to a study of the antibody response to experimental infection with A. suum.

3. Using an alcoholic extract of uterus, oviducts and ovaries of the adult female Ascaris worm as antigen, antibodies against this nematode were first detected in two experimentally infected pigs ten days after infection. A peak of antibody concentration from the thirteenth to the seventeenth day of infection was followed by a decline in the antibody content of the serum to the forty-first day; after which no antibody was detected.

Type
Research Article
Information
Journal of Helminthology , Volume 35 , Issue 3-4 , September 1961 , pp. 319 - 344
Copyright
Copyright © Cambridge University Press 1961

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