Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-03T05:06:04.004Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunological Studies on Experimental Infection of Guineapigs and Rabbits with Ascaris suum Goeze, 1782. II. —Antibody Production and the Further Demonstration of Acquired Resistance in Guineapigs*

Published online by Cambridge University Press:  18 November 2009

L. F. Taffs
L. F. Taffs
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Cambridge**
Get access Rights & Permissions [Opens in a new window]

Extract

Guineapigs infected by mouth with eggs of A. suum developed an acquired resistance to reinfection 27, 35 and 51 days later. Resistance of the host was manifested by: survival following a lethal dose of eggs; an inhibition of larval migration; a retardation of larval growth; and the ability to maintain or gain weight.

By means of the conglutinating complement absorption test, using a saline extract of worm as antigen, antibodies were detected in the serum of resistant guineapigs seven days after the second reinfection. Antibodies were not detected in the serum of nonresistant guineapigs seven days after one infection. There was some evidence to indicate that the conglutinating antibody titre of the serum is a measure of the host's ability to resist infection.

Type
Research Papers
Information
Journal of Helminthology , Volume 38 , Issue 3-4 , December 1964 , pp. 315 - 324
Copyright
Copyright © Cambridge University Press 1964

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Coventry, F. A., 1929.—“Hypersensitiveness to helminth proteins. II. Cutaneous and precipitin tests with Ascaris extracts in infected and immunized animals.” J. prev. Med., Baltimore, 3, 43–62.Google Scholar
Fallis, A. M., 1948.—“Ascaris lumbricoides infection in guinea pigs with special reference to eosinophilia and resistance.” Canad. J. Res., 26, 307–327.CrossRefGoogle ScholarPubMed
Oliver-Gonzalez, J., 1943.—“Antigenic analysis of the isolated tissues and body fluids of the roundworm, Ascaris lumbricoides var. suum.” J. infect. Dis., 72, 202–212.CrossRefGoogle Scholar
Soulsby, E. J. L., 1957a.—“Immunization against Ascaris lumbricoides in the guinea pig.” Nature, Lond., 179, 783.Google Scholar
Soulsby, E. J. L., 1957b.—“Some immunological phenomena in parasitic infections.” Vet. Rec., 69, 1129–1136.Google Scholar
Sprent, J. F. A. and Chen, H. H., 1949.—“Immunological studies in mice infected with the larvae of Ascaris lumbricoides. I. Criteria of immunity and immunizing effect of isolated worm tissues.” J. infect. Dis., 84, 111–124.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1961.—“The in vitro action of immune pig serum on second-and third-stage Ascaris suum larvae.” Parasitology, 51, 327–334.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1962.—“Immunological studies on the Ascaris of man and pig.” Parasitology, 52, 4P–5P.Google Scholar
Taffs, L. F., 1963.—“Immunological studies on experimental infection of pigs with Ascaris suum Goeze, 1782. II. The use of the conglutinating complement absorption test for the demonstration of Ascaris antibody.” J. Helminth., 37, 369–380.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1964.—“Immunological studies on experimental infection of guineapigs and rabbits with Ascaris suum Goeze, 1782. I. The minimum lethal dose (M.L.D.) and the minimum immunizing dose (M.I.D.) of Ascaris eggs in guineapigs.” J. Helminth., 38, 303–314.CrossRefGoogle Scholar
Taliaferro, W. H. and Sarles, M. P., 1939.—“The cellular reactions in the skin, lungs and intestine of normal and immune rats after infection with Nippostrongylus muris.” J. infect. Dis., 64, 157–192.CrossRefGoogle Scholar