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Immunodiagnosis of human filariasis by counterimmunoelectrophoresis using Litomosoides carinii antigens

Published online by Cambridge University Press:  05 June 2009

A. Dasgupta ,
Shukal Bala ,
A. Banerjee  and
A. Chaudhury
A. Dasgupta
Affiliation:
Immunology Division, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, 16, India
Shukal Bala
Affiliation:
Immunology Division, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, 16, India
A. Banerjee
Affiliation:
Immunology Division, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, 16, India
A. Chaudhury
Affiliation:
Immunology Division, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, 16, India
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Abstract

The presence of precipitin antibody and soluble circulating antigen was demonstrated in sera of individuals with clinical filariasis by counterimmunoelectrophoresis. Antigens derived from Litomosoides carinii and antisera raised in rabbits to the adult worm antigens were used for the detection of antibody and antigen in human sera. Of 35 subjects, 2 had microfilariae in the peripheral blood, 9 soluble circulating antigen, 19 antibody in sera, and 6 had both antigen and antibody. It suggests that 5.7% of cases diagnosed as bancroftian filariasis by parasitological examination can be increased to 62.8% by serological means.

Type
Research Papers
Information
Journal of Helminthology , Volume 54 , Issue 2 , June 1980 , pp. 83 - 86
Copyright
Copyright © Cambridge University Press 1980

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References

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