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Immunity to adult Heligmosomoides polygyrus (Nematospiroides dubius): survival or rejection of adult worms following transplantation to mice refractory to larval challenge

Published online by Cambridge University Press:  05 June 2009

M. Robinson ,
J. M. Behnke  and
D.J.L. Williams
M. Robinson
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, University Park, Nottingham, NG7 2RD, England
J. M. Behnke*
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, University Park, Nottingham, NG7 2RD, England
D.J.L. Williams
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, University Park, Nottingham, NG7 2RD, England
*
2Author to whom all correspondence should be addressed.
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Abstract

Experiments were carried out to explore the survival of 14-day adult H. polygyrus following transplantation to mice of four strains, immunized by various protocols. Adult worm establishment and survival was unimpaired in CFLP mice which were totally refractory to larval challenge. Transplanted adult worms were also successful in NIH mice immunized by the 9-day abbreviated infection regime. However, NIH mice exposed to irradiated larvae or subjected to the divided primary infection, expelled transplanted adults. The 9-day abbreviated infection was further examined in SJL and (C57 Bl10 X NIH) F1 mice which expel adult worms during a primary infection and although this regime was unsuccessful in causing NIH mice to reject adult worms, expulsion of adult worms was accelerated in SJL and F1 mice. The survival of adult H. polygyrus was discussed in the context of stage-specific immunity and the delicate balance between the immunogenic stimuli from developing larvae, the immunomodulatory activities of adult stages and the host's genetically determined capacity to respond to these opposing signals.

Keywords

Heligmosomoides polygyrusNematospiroides dubiusintestinal immunityimmunomodulationmiceimmunization
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 3 , September 1988 , pp. 221 - 231
Copyright
Copyright © Cambridge University Press 1988

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References

REFERENCES

Ali, N. M. H. & Behnke, J. M. (1985) Observations on the gross changes in the secondary lymphoid organs of mice infected withNematospiroides dubius. Journal of Helminthology, 59, 167–174.CrossRefGoogle ScholarPubMed
Bartlett, A. & Ball, P. A. J. (1974) The immune response of the mouse to larvae and adults of Nematospiroides dubius. International Journal for Parasitology, 4, 463–470.CrossRefGoogle ScholarPubMed
Behnke, J. M. (1987) Evasion of immunity by nematode parasites causing chronic infections. Advances in Parasitology, 26, 1–71.CrossRefGoogle ScholarPubMed
Behnke, J. M., Hannah, J. & Pritchard, D. I. (1983) Nematospiroides dubius in the mouse: evidence that adult worms depress the expression of homologous immunity. Parasite Immunology, 5, 397–408.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Parish, H. A. (1979) Expulsion of Nematospiroides dubius from the intestine of mice treated with immune serum. Parasite Immunology, 1, 13–16.CrossRefGoogle ScholarPubMed
Behnke, J. M., Parish, H. A. & Hagan, P. (1980) The effect of gamma irradiation on Nematospiroides dubius. Factors affecting the survival of worms in a primary infection in mice. Journal of Helminthology, 54, 173–182.CrossRefGoogle Scholar
Behnke, J. M. & Robinson, M. (1985) Genetic control of immunity to Nematospiroides dubius: a 9 day anthelmintic abbreviated immunising regime which separates weak and strong responder strains of mice. Parasite Immunology, 7, 235–253.CrossRefGoogle ScholarPubMed
Behnke, J. M. & Wakelin, D. (1977) Nematospiroides dubius: stimulation of acquired immunity in inbred strains of mice. Journal of Helminthology, 51, 167–176.CrossRefGoogle ScholarPubMed
Behnke, J. M., Williams, D. J., Hannah, J. & Pritchard, D. I. (1987) Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): the capacity of adult worms to survive following transplantation to recipient mice. Parasitology, 95, 569–581.CrossRefGoogle ScholarPubMed
Cypess, R. H., Lucia, H. L., Zidian, J. L. & Rivera-Ortez, C. I. (1977) Heligmosomoides polygyrus: temporal, spatial and morphological population characteristics in LAF1/J mice. Experimental Parasitology, 42, 34–43.CrossRefGoogle ScholarPubMed
Day, K. P., Howard, R. J., Prowse, S. J., Chapman, C. B. & Mitchell, G. F. (1979) Studies on chronic versus transient intestinal nematode infections in mice. 1. A comparison of responses to excretory/secretory (ES) products of Nippostronglyus brasiliensis and Nematospiroides dubius worms. Parasite Immunology, 1, 217–239.CrossRefGoogle Scholar
Dehlawi, M. S., Wakelin, D. & Behnke, J. M. (1987) Suppression of mucosal mastocytosis by infection with the intestinal nematodeNematospiroides dubius. Parasite Immunology, 9, 187–199.CrossRefGoogle ScholarPubMed
Dobson, C. (1982) Passive transfer of immunity with serum in mice infected with Nematospiroides dubius: influence of quality and quantity of immune serum. International Journal for Parasitology, 12, 207–213.CrossRefGoogle ScholarPubMed
Ehrenford, F. A. (1954) The life cycle of Nematospiroides dubius Baylis (Nematoda; Heligmosomidae) Journal of Parasitology, 40, 480–481.CrossRefGoogle Scholar
Hagan, P., Behnke, J. M. & Parish, H. A. (1981) Stimulation of immunity to Nematospiroides dubius in mice using larvae attenuated by cobalt 60 irradiation. Parasite Immunology, 3, 149–156.CrossRefGoogle ScholarPubMed
Jacobson, R. H., Brooks, B. O. & Cypress, R. H. (1982) Immunity to Nemotospiroides dubius: parasite stages responsible for and subject to resistance in high responder (LAF1/JAF) mice. Journal of Parasitology, 68, 1053–1058.CrossRefGoogle Scholar
Jenkins, S. N. & Behnke, J. M. (1977) Impairment of primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius. Parasitology, 75, 71–78.CrossRefGoogle ScholarPubMed
Keymer, A. E. & Hiorns, R. W. (1986) Heligmosomoides polygyrus (Nematoda): the dynamics of primary and repeated infection in outbred mice. Proceedings of the Royal Society of London, 29, 47–67.Google Scholar
Mitchell, G. F., Anders, R. F., Brown, G. V., Handman, E., Roberts-Thomson, I. C., Chapman, C. B., Forsyth, K. P., Kahl, L. P. & Cruise, K. M. (1982) Analysis of infection characteristics and antiparasite immune responses in resistant compared with susceptible hosts. Immunological Reviews, 61, 137–188.CrossRefGoogle ScholarPubMed
Mitchell, G. F. & Cruise, K. M. (1984) Immunization with Nematospiroides dubius adult worms plus pertussigen has different consequences in mice of various genotypes. Australian Journal of Experimental Biology and Medical Science, 62, 523–530.CrossRefGoogle ScholarPubMed
Mitchell, G. F. & Munoz, J. J. (1983) Vaccination of genetically susceptible mice against chronic infection with Nematospiroides dubius using pertussigen as adjuvant. Australian Journal of Experimental Biology and Medical Science, 61, 425–434.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. & Jones, V. E. (1973) Immunity in the parasitic relationship between helminths and hosts. Progress in Allergy, 17, 93–144.Google ScholarPubMed
Pritchard, D. I., Maizels, R. M., Behnke, J. M. & Appleby, P. (1984) Stage-specific antigens of Nematospiroides dubius. Immunology, 53, 325–335.Google ScholarPubMed
Robinson, M., Wahid, F. N., Behnke, J. M. & Gilbert, F. S. Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius) = dose-dependent expulsion of adult worms. Parasitology, in press.Google Scholar
Sitepu, P. & Dobson, C. (1982) Genetic control of resistance to infection with Nematospiroides dubius in mice: selection of high and low immune response populations of mice. Parasitology, 85, 73–84.CrossRefGoogle ScholarPubMed
Sokal, R. R. & Rohlf, F. J. (1969) Biometry. San Francisco: Freeman.Google Scholar