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Further studies on the effect of cyclosporin A on the course of Paragonimus infection in rats

Published online by Cambridge University Press:  05 June 2009

Yoshihisa Hashiguchi  and
Yoshisuke Okamura
Yoshihisa Hashiguchi
Affiliation:
Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781–51, Japan
Yoshisuke Okamura
Affiliation:
Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781–51, Japan
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Abstract

Paragonimus ohirai-infected rats were treated with cyclosporin A (CyA) at different times during the course of infection. CyA (5×80 mg/kg) affected the worm recovery, growth and maturation rates of P. ohirai with respect to control values. This tendency was most remarkable in animals treated 15 days and more after infection with CyA (groups B, +15 to +19 days; C, +25 to +29; D, +35 to +39 and E, +45 to +49). In group A (0 to +4), however, the drug did not affect markedly the growth and maturation of worms, although it significantly lowered worm recovery rates. CyA administration also affected normal migration of P. ohirai in the highly susceptible host (rat), when the drug was administered during the peritoneal and/or liver phase of infection. Thus, in this P. ohirai/rat model, CyA significantly reduced worm recovery rates, and affected the growth, maturation and migration of the worms depending on the time of administration.

Keywords

Paragonimus ohiraicyclosporin Aratimmunosuppressants
Type
Research Article
Information
Journal of Helminthology , Volume 63 , Issue 4 , December 1989 , pp. 328 - 332
Copyright
Copyright © Cambridge University Press 1989

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References

REFERENCES

Borel, J. F., Feurer, C., Gubler, H. V. & Stahelin, H. (1976) Biological effects of cyclosporin A: a new antilymphocytic agent. Agents and Actions, 6, 468–475.CrossRefGoogle ScholarPubMed
Bout, D., Deslee, D. & Capron, A. (1984a) Protection against schistosomiasis produced by cyclosporin A. American Journal of Tropical Medicine and Hygiene, 78, 670–671.CrossRefGoogle Scholar
Bout, D., Haque, A. & Capron, A. (1984b) Filaricidal effects of cyclosporin A against Dipetalonema viteae in Mastomys natalensis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 78, 670–671.CrossRefGoogle ScholarPubMed
Bueding, E., Hawkins, J. & Cha, Y. N. (1981) Antischistosomal effects of cyclosporin A. Agents and Actions, 11, 380–383.CrossRefGoogle ScholarPubMed
Hashiguchi, Y. (1973) Biological studies on the host-parasite relationships between the lung flukes. Paragonimus spp., and some murine mammals. Research Reports of the Kochi University, 22, 27–102.Google Scholar
Hashiguchi, Y. & Okamura, Y. (1988) The effects of cyclosporin A on the course of Paragonimus miyazakii infection in rats. Journal of Helminthology, 62, 251–256.CrossRefGoogle ScholarPubMed
Hashiguchi, Y., Takei, T. & Miyazaki, I. (1969) Studies on a single worm infection of albino rats with Paragonimus ohirai Miyazaki, 1939. Japanese Journal of Parasitology, 18, 612–617.Google Scholar
Nilsson, L. A., Lindblad, R., Olling., S. & Ouchterlony, O. (1985) The effect of cyclosporin A on the course of murine infection by Schistosoma mansoni. Parasite Immunology, 7, 19–27.CrossRefGoogle ScholarPubMed
Ohkura, T. (1963) Studies on the development of Paragonimus ohirai Miyazaki. 1939 in the final hosts. 2. The development of P. ohirai in rats. Japanese Journal of Parasitology, 12, 99–118.Google Scholar
Zahner, H. & Schultheiss, K. (1987) Effect of cyclosporin A and some derivatives in Litomosoides carinii-infected Mastomys natalensis. Journal of Helminthology, 61, 282–290.CrossRefGoogle ScholarPubMed