Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-10T19:03:40.418Z Has data issue: false hasContentIssue false
  • English
  • Français

Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. V. Reduction in the degree of resistance to reinfection after chemotherapeutic elimination of recently patent primary infections

Published online by Cambridge University Press:  05 June 2009

M. Doenhoff ,
Q. Bickle ,
J. Bain ,
G. Webbe  and
G. Nelson
M. Doenhoff
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 0XQ, England
Q. Bickle
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 0XQ, England
J. Bain
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 0XQ, England
G. Webbe
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 0XQ, England
G. Nelson
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 0XQ, England
Get access Rights & Permissions [Opens in a new window]

Abstract

Effective treatment of mice with six to eight week-old patent S. mansoni infections with any one of five schistosomicidal agents (Oxamniquine, Praziquantel, potassium antimony tartrate, Niridazole and Hycanthone) resulted in a reduction in the degree of resistance to homologous challenge in the treated animals when compared with the level of resistance to reinfection observed in untreated mice with intact primary infections. Mice challenged five to six weeks after treatment with Praziquantel, Niridazole or Hycanthone demonstrated a lower level of resistance than mice challenged within 10 days of the termination of the chemotherapeutic schedules. Direct comparison of Praziquantel with potassium antimony tartrate indicated that treatment with the former drug allowed retention of a greater level of acquired resistance than the antimonial in the immediate post-treatment period. Resistance to reinfection in Hycanthone-treated mice was not restored by intravenous injection of S. mansoni eggs before challenge.

Type
Research Papers
Information
Journal of Helminthology , Volume 54 , Issue 1 , March 1980 , pp. 7 - 16
Copyright
Copyright © Cambridge University Press 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bickle, Q., Bain, J., McGregor, A. and Doenhoff, M.. (1979) Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. III. The failure of primary infections with cercariae of one sex to induce resistance to reinfection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 73, 37–41.Google Scholar
Campbell, W. C. (1963) Attempts to demonstrate immunity to Schistosoma mansoni in mice previously subjected to chemically abbreviated infections. Journal of Parasitology. 49, 824–829.CrossRefGoogle ScholarPubMed
Cheever, A. W.de Witt, W. B. and Warren, K. S. (1965) Repeated infection and treatment of mice with Schistosoma mansoni: Functional, anatomic and immunologic observations. American Journal of Tropical Medicine and Hygiene, 14, 239–253.Google Scholar
Dean, D. A., Minard, P., Vannier, W. E. and Murrell, K. D. (1978a) Resitance of mice to secondary infection with Schistosoma mansoni. II. Evidence of a correlation between egg deposition and worm elimination. American Journal of Tropical Medicine and Hygiene, 27, 957–965.Google Scholar
Dean, D. A., Minard, P., Stirewalt, M. A., Vannier, W. E. and Murrell, K. D.. (1978b) Resistance of mice to secondary infection with Schistosoma mansoni. I. Comparison of bisexual and unisexual initial infections. American Journal of Tropical Medicine and Hygiene, 27, 951–956.Google Scholar
Doenhoff, M., Bickle, Q., Long, E., Bain, J. and McGregor, A. (1978) Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. I. Demonstration of resistance to reinfection using a model system that involves perfusion of mice within three weeks of challenge. Journal of Helminthology, 52, 173–186.CrossRefGoogle Scholar
Foster, R. and Cheetham, R. L. (1973) Studies with the schistosomicide Oxamniquine (UK-4271). I. Activity in rodents and in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 67, 674–684.Google Scholar
Gold, D. and Lengy, J. (1975) Failure to immunize mice against Schistosoma mansoni by therapeutic eradication of the adult worm burden. Annals of Tropical Medicine and Parasitology, 69, 265–266.CrossRefGoogle ScholarPubMed
Gönnert, R. and Andrews, P. (1977) Praziquantel, a new broad-spectrum antishistosomal agent. Zeitschrift für Parasitenkunde, 52, 129–150.CrossRefGoogle Scholar
Hunter, W. B., Crandall, R. B., Zickafoose, D. E. and Purvis, Q. B. (1962) Studies on schistosomiasis XVIII. Some factors affecting resistance to Schistosoma mansoni infections in albino mice. American Journal of Tropical Medicine and Hygiene, 11, 17–24.Google Scholar
Kagan, I. G. and Lee, C.-L. (1953) Duration of acquired immunity of Schistosomatium douthitti infections in mice following treatment. Journal of Infections Diseases, 92, 52–57.CrossRefGoogle ScholarPubMed
Long, E., Doenhoff, M. and Bain, J. (1978) Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. 2. The time at which resistance to reinfection develops. Journal of Helminthology, 52, 187–191.CrossRefGoogle ScholarPubMed
Mahmoud, A. A. F., Mandel, M. A., Warren, K. S. and Webster, L. T. (1975) Niridazole, II: A potent long acting suppressant of cellular hypersensitivity. Journal of Immunology, 114, 279–283.CrossRefGoogle Scholar
Phillips, S. M., Reid, W. A., Doughty, B. and Khoury, P. B. (1978) The cellular and humoral immune response to Schistosoma mansoni infections in inbred rats. V: Prerequisite mechanisms for the development of optimal protective immunity. Cellular Immunology, 38, 225–238.CrossRefGoogle ScholarPubMed
Smithers, S. R. and Terry, R. J. (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology, 55, 695–700.CrossRefGoogle ScholarPubMed
Smithers, S. R. and Terry, R. J. (1969) Immunity in schistosomiasis. Annals of the New York Academy of Sciences, 160, 826–480.Google Scholar
Taylor, M. G., Amin, M. B. A. and Nelson, G. S. (1969) “Parthenogenesis” in Schistosoma mattheei. Journal of Helminthology, 43, 197–206.CrossRefGoogle Scholar
Warren, K. S., Pelley, R. P. and Mahmoud, A. A. F. (1977) Immunity and immunopathology following reinfection of mice cured of chronic schistosomiasis mansoni. American Journal of Tropical Medicine and Hygiene, 26, 957–962.Google Scholar