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Evaluation of broad-spectrum anthelmintic activity in a novel assay against Haemonchus contortus, Trichostrongylus colubriformis and T. sigmodontis in the gerbil Meriones unguiculatus

Published online by Cambridge University Press:  12 April 2024

D.A. Ostlind ,
S. Cifelli ,
W.G. Mickle ,
S.K. Smith ,
D.V. Ewanciw ,
B. Rafalko ,
T. Felcetto  and
A. Misura
D.A. Ostlind*
Affiliation:
94 Dreahook Road, Whitehouse Station, NJ 08889, USA
S. Cifelli
Affiliation:
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
W.G. Mickle
Affiliation:
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
S.K. Smith
Affiliation:
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
D.V. Ewanciw
Affiliation:
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
B. Rafalko
Affiliation:
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
T. Felcetto
Affiliation:
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
A. Misura
Affiliation:
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA
*
*Corresponding author: Fax: 908 236 9238, Email: [email protected]
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Abstract

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The gerbil Meriones unguiculatus, infected with three species of nematodes, each located in a separate part of the gastrointestinal tract, provided a reliable laboratory assay for the evaluation of broad-spectrum anthelmintic activity. Gerbils harbouring 6-day-old infections of Haemonchus contortus, Trichostrongylus colubriformis and T. sigmodontis were given selected broad-spectrum anthelmintics by gavage. Three benzimidazoles, thiabendazole, oxfendazole and albendazole, a tetrahydropyrimidine, morantel, an imidazothiazole, levamisole hydrochloride, a macrocyclic lactone, ivermectin and an experimental natural product, paraherquamide, were active against all three nematodes at various dosages. Trichostrongylus colubriformis was most sensitive to levamisole hydrochloride, morantel, thiabendazole and paraherquamide whereas ivermectin, oxfendazole and albendazole were more effective against H. contortus. All compounds were active against the caecal nematode T. sigmodontis although it was less sensitive than T. colubriformis. Haemonchus contortus was more sensitive than T. sigmodontis to all anthelmintics tested except thiabendazole.

Type
Research Article
Information
Journal of Helminthology , Volume 80 , Issue 4 , December 2006 , pp. 393 - 396
Copyright
Copyright © Cambridge University Press 2006

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