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Eosinophilia in chimeric mice infected with Toxocara canis

Published online by Cambridge University Press:  05 June 2009

Kazuo Sugane  and
Tadashi Matsuura
Kazuo Sugane
Affiliation:
Department of Parasitology, School of Medicine, Shinshu University, Asahi 3–1–1 Matsumoto City, Japan
Tadashi Matsuura
Affiliation:
Department of Parasitology, School of Medicine, Shinshu University, Asahi 3–1–1 Matsumoto City, Japan
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Abstract

A marked strain variation in eosinophilia following oral infection with Toxocara canis eggs was observed in mice. Mutual radiation chimeras between high and low responder mice in terms of eosinophilia were made and compared with the respective donor and recipient for eosinophilia after the infection. As a result, the degree and time course of eosinophilia in chimeric mice were similar to those in donors. The result suggested that genes which regulate inheritance of the trait, marked eosinophilia in T. canis-infected mice, might be expressed in bone marrow derived cells.

Keywords

Toxocara canismouseeosinophilia
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 2 , June 1987 , pp. 157 - 162
Copyright
Copyright © Cambridge University Press 1987

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