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Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis

Published online by Cambridge University Press:  01 March 2007

P.C. Shih ,
H.H. Lee ,
S.C. Lai ,
K.M. Chen ,
S.T. Jiang ,
Y.F. Chen  and
S.J. Shiow
P.C. Shih
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
H.H. Lee
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
S.C. Lai
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
K.M. Chen
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
S.T. Jiang
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
Y.F. Chen
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
S.J. Shiow*
Affiliation:
Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 402, Taiwan
*
*Author for correspondence Fax: (886) 4 23823381 E-mail: [email protected]
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Abstract

Angiostrongylus cantonensis can invade the central nervous system, leading to human eosinophilic meningitis or eosinophilic meningoencephalitis. Curcumin is a natural product which has the effects of anti-inflammation, anti-oxidation and anti-carcinogensis, while the administration of curcumin has been reported to possibly relieve the symptoms of meningitis. The present study tested the potential efficacy of curcumin in A. cantonensis-induced eosinophilic meningitis of BALB/c mice. Assay indicators for the therapeutic effect included the larvicidal effect, eosinophil counts and matrix metalloproteinase-9 (MMP-9) activity in angiostrongyliasis. Eosinophils were mildly reduced in treatment groups compared with infected-untreated mice. However, there were no significant differences in larvicidal effects or MMP-9 activity. This study suggests that anti-inflammatory treatment with curcumin alone has low efficacy, but the treatment does not interfere with MMP-9 expression and is not useful for larvicidal effects. The possible reasons include low curcumin across the blood–brain barrier and also those larvae that survive stimulate MMP-9 production, which promotes blood–brain barrier damage, with leukocytes then crossing the blood–brain barrier to cause meningitis. Further studies will be required to test these possibilities.

Type
Research Papers
Information
Journal of Helminthology , Volume 81 , Issue 1 , March 2007 , pp. 1 - 5
Copyright
Copyright © 2007 Cambridge University Press 2007

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