Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-23T21:27:08.207Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of concurrently administered copper and mercury on phagocytic cell activity and antibody levels in guinea pigs with experimental ascariasis

Published online by Cambridge University Press:  05 June 2009

J. Šoltýs ,
Z. Borošková  and
E. Dvorožňáková
J. Šoltýs
Affiliation:
Parasitological Institute, Slovak Academy of Sciences, Hlinkova 3, Košice, Slovak Republic
Z. Borošková
Affiliation:
Parasitological Institute, Slovak Academy of Sciences, Hlinkova 3, Košice, Slovak Republic
E. Dvorožňáková
Affiliation:
Parasitological Institute, Slovak Academy of Sciences, Hlinkova 3, Košice, Slovak Republic
Get access Rights & Permissions [Opens in a new window]

Abstract

The subchronic effect of copper and mercury on selected immunological parameters in guinea pigs with experimental ascariasis was studied. Cupric sulphate and mercuric chloride administered for 28 days did not suppress the levels of specific circulating antibody in a subsequent Ascaris suum infection. Intoxication of animals significantly inhibited the phagocytic activity of peritoneal macrophages throughout the experiment. Ascaris suum infection elevated macrophage phagocytic activity but values remained significantly lower in comparison with infected non-intoxicated animals. Both the concurrently administered metal compounds changed the phagocytic ability of polymorphonuclear leucocytes in the blood.

The intensity of infection assessed by the number of Ascaris larvae migrating in the lungs of animals currently intoxicated with both the metal compounds increased by 28.6%, compared with controls.

Type
Research Papers
Information
Journal of Helminthology , Volume 71 , Issue 4 , December 1997 , pp. 339 - 344
Copyright
Copyright © Cambridge University Press 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anon. (1986) Manual of veterinary parasitological laboratory techniques. 24 pp. Ministry of Agriculture, Fisheries and Food. Her Majesty's Stationery Office.Google Scholar
Bencko, V., Cikrt, M. & Lener, J. (1984) The toxic metals in environment. 220 pp. Prague, Avicenum.Google Scholar
Boroŝkováa, Z., Ŝoltýs, J. & Benková, M. (1995) Effect of mercury on the immune response and mean intensity of Ascaris suum infection in guinea pig. Journal of Helminthology 69, 187–194.CrossRefGoogle Scholar
Boroŝková, Z., Ŝoltýs, J. & Benková, M. (1996) Effect of copper on the immune responses of guinea pigs with experimental ascariosis. Veterinární Medicina (Czech) 41,13–18.Google Scholar
Blackley, B.R., Sisodia, C.S. & Mukkur, T.K. (1980) The effect of methylmercury, tetraethyl lead and sodium arsenide on the humoral immune response in mice. Toxicology and Pharmacology 52, 254–255.Google Scholar
Ding, A.H., Nathan, C.F. & Stuehr, D.J. (1988) Release of reactive nitrogen intermedias from mouse peritoneal macrophages. journal of Immunology 147, 2407–2413.CrossRefGoogle Scholar
Funk, A.E., Day, F.A. & Brady, O.F. (1987) Displacement of Zn and Cu from copper-induced metallothionein by cadmium and by mercury: in vivo and ex vivo studies. Comparative Biochemistry and Physiology 86,1–6.Google ScholarPubMed
Jones, W.O. & Symons, L.E.A. (1982) The effect of copper deficiency on leucocyte function in sheep and cattle. Research in Veterinary Science 31,151–156.CrossRefGoogle Scholar
Joseph, M. (1982) Effector functions of phagocytic cells against helminths. Clinical Immunology and Allergology 3, 567–569.CrossRefGoogle Scholar
Koller, D.L. & Vos, J.G. (1981) Immunological effect of metals, pp. 67–78in Sharme, R.P. (Ed.) Immunologic considerations in toxicology. Vol. 1, Boca Raton, Florida, CRC Press.Google Scholar
Koller, D.L., Exon, J.H. & Brauner, J.A. (1977) Methylmercury: Decreased antibody formation in mice. Proceedings of the Society for Experimental Biology and Medicine 155, 602–604.CrossRefGoogle ScholarPubMed
Lawrence, D., Mudzinski, S., Rudosfsky, U. & Warner, J. (1987) Mechanism of metal-induced immunotoxicity. p. 17in Berlin, A., Dean, J.H., Smith, E.M.R. & Spreafico, F. (Eds) Immunotoxicology. The Netherlands, Kluwer Academic Publ.Google Scholar
Manĉal, J. (1986) Immunoenzyme analysis methods, pp. 12–23. Prague, ÚSOL.Google Scholar
Ohi, G., Fukuda, M., Seto, H. & Yagaya, H. (1976) Effect of methylmercury on humoral immune response in mice under conditions simulated to practical situations. Bulletin of Environmental Contamination and Toxicology 15, 175.CrossRefGoogle ScholarPubMed
Philips, D.R., Chappell, R.J. & Hayes, J. (1982) A possible role of Cu2+ ions in bovine antibody-antigen interaction. Research in Veterinary Science 32, 221–224.CrossRefGoogle Scholar
Sawicka-Kapusta, R., Rozlowski, J. & Sokolowska, T. (1986) Heavy metals in tits from polluted forest in southern Poland. Environmental Pollution 42, 297–310.CrossRefGoogle Scholar
Šoltýs, J., Borošková, Z. & Benková, M. (1994) Comparison of the acute and subacute effect of the industrial heavy metal emission on the cellular immunity of guinea pigs with experimental ascariosis. Helminthologia 31,111–116.Google Scholar
Soulsby, E.J.L. (1987) Immunology, immunopathology and immunoprophylaxis of Ascaris spp. pp. 127–140in Soulsby, E.J.L. (Ed.) Immune responses in parasitic infections. Vol. 1. Florida, CRC Press Inc.Google Scholar
Toman, M. & Pšikal, J. (1985) Test of the phagocytic activity in calves. Veteriánrní Medicina (Czech) 7, 393–400.Google Scholar
Wagner, W. & Wagnerová, M. (1988) Ecoimmunology. pp. 122–144. Prague, Avicenum.Google Scholar