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The Effect of Cambendazole on Trichinella spiralis Infections in Mice

Published online by Cambridge University Press:  05 June 2009

M.G. Duckett  and
D.A. Denham
M.G. Duckett
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London, W.C.I
D.A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London, W.C.I
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Extract

Gavage administration of cambendazole at 50 mg/kg was found to eliminate a 7 hour Trichinella spiralis infection in mice. Cambendazole was also found to be highly active against the muscle phase of trichinosis. Partial activity was also indicated against migratory larvae and adult worms. Cambendazole appears to have a sterilising effect on adult T. spiralis. It is postulated that cambendazole has potential therapeutic value.

Type
Research Article
Information
Journal of Helminthology , Volume 44 , Issue 2 , June 1970 , pp. 211 - 218
Copyright
Copyright © Cambridge University Press 1970

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References

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