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Dissociation of the protective immune response in the mouse to Strongyloides ratti

Published online by Cambridge University Press:  05 June 2009

David I. Grove  and
Carolyn Northern
David I. Grove
Affiliation:
Department of Postgraduate Medical Education, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009
Carolyn Northern
Affiliation:
Department of Postgraduate Medical Education, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009
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Abstract

The generation of protective immunity by various stages in the life-cycle of Strongyloides ratti and the phases against which resistance is directed has been examined in murine strongyloidiasis. Mice were exposed to natural, complete infections, were treated with thiabendazole (which largely resembles the natural infection), were treated with cambendazole (which restricts infection to the larval stage), or infected directly by oral transfer of adult worms. Mice that were infected with infective larvae alone did not become resistant to infective larvae or the complete infection but were resistant to adult worms implanted directly into the gut. Mice exposed to adult worms alone were resistant to natural infections and adults worms implanted directly but were not resistant to infective larvae. On the other hand, mice that had received prior natural infections showed evidence of resistance to infective larvae, adult worms, and natural, complete infections. It is concluded that there is immunological cross-reactivity between infective larvae and adult worms but that under certain circumstances the infective larvae are able to evade the host's protective immune response.

Keywords

Strongyloides rattiimmune responsemouse
Type
Research Article
Information
Journal of Helminthology , Volume 63 , Issue 4 , December 1989 , pp. 307 - 314
Copyright
Copyright © Cambridge University Press 1989

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