Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-05T08:07:28.819Z Has data issue: false hasContentIssue false
  • English
  • Français

Cortisone-sensitive, innate resistance to Hymenolepis nana infection in congenitally athymic nude rats

Published online by Cambridge University Press:  05 June 2009

Akira Ito  and
Tsuneo Kamiyama
Akira Ito
Affiliation:
Department of Parasitology, Gifu University School of Medicine, Tsukasa-Machi 40, Gifu 500, Japan
Tsuneo Kamiyama
Affiliation:
Department of Veterinary Science, National Institute of Health, Kamiosaki 2 Chome, Shinagawaku, Tokyo 141, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

The innate resistance of the unnatural rat host to the mouse tapeworm Hymenolepis nana is cortisone sensitive but thymus independent. When congenitally athymic nude rats were orally given eggs, cysticercoids, or adult worms of H. nana, no lumenal adults were established except when they were treated with cortisone acetate during the expected lumenal development. The effect of cortisone to promote adult maturation in the rats was compared in nude and normal rats given eggs of H. nana. The fecundity of the worm (assessed by the fresh worm biomass and the number of infective eggs produced) was much higher in cortisone-treated nude rats than in cotrisone-trated norml rats. When the nude rats recostituted with thymocytes were given eggs and treated with cortisone, the fecundity of H. nana dropped to the same level as in cortisone-treated normal rats. It is strongly suggested that the unnatural rat host has thymus-independent cortisone sensitive resistance to an intial infection (which is the main component of the innate resistance and blocks the lumenal establishment of this parasite) and thymus-dependent resistance (which suppresses the established worm' fecudity and may be ascribed to acquired resistance to the ongoing infection).

Keywords

Hymenolepis nanaratresistancecortisone
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 2 , June 1987 , pp. 124 - 128
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Andreassen, J., Hindsbo, O. & Vienberg, S. (1982) Responsiveness of congenitally thymus deficient nude mice to the intestinal cestode, Hymenolepis diminuta. International Journal for Parasitology, 12, 215–219.CrossRefGoogle Scholar
Heyneman, D. (1962) Studies on helminth immunity: II. Influence of Hymenolepis nana (Cestoda: Hymenolepididae) in dual infection with H. diminuta in white mice and rats. Experimental Parasitology, 12, 7–18.CrossRefGoogle Scholar
Ito, A. (1980) Hymenolepis nana: Survival in the immunized mouse. Experimental Parasitology, 49, 248–257.CrossRefGoogle ScholarPubMed
Ito, A. (1981) Comparison of the kinetics fo infection with Hymenolepis nana between BALB/c and dd strains of mice. Japanese Journal of Parasitology, 30, 439–446.Google Scholar
Ito, A. (1982) Induction of adult formation from cysticercoid of Hymenolepis nana established in Fischer (F344) rat with cortisone acetate. Japanese journal of Parasitology, 31, 141–146.Google Scholar
Ito, A. (1983) Hymenolepis nana: Maturation in an immunosuppressed unnatural rat host. Experimental Parasitology, 56, 318–326.CrossRefGoogle Scholar
Ito, A. (1985) Thymus dependency of the host resistance to infection with Hymenolepis nana (cestode) in the natural mouse and unnatural rat hosts. In: Genetic Control of Host Resistance to Infection and Malignancy (editor. Skamene, E.) pp. 471–476. Alan R. Liss: New York.Google Scholar
Ito, A. & Kamiyama, T. (1984). Hymenolepis nana: Comparision of worm recovery between congenitally athymic nude and phenotypically normal rats and mice. Experimental Parasitology, 58, 132–137.CrossRefGoogle Scholar
Ito, A. & Smyth, J. D. (1987) Adult Cestodes. Immunology of the lumen-dwelling cestode infections. In: Immune Responses in Parasitic Infections: The Immunology, Immunopathology, and immunoprophylaxis (editor, Soulsby, E. J. L.) Vol. 2. CRC Press: Boca Raton. (in press).Google Scholar
Ito, A., Kano, S., Hioki, A., Kasuya, S. & Ohtomo, H. (1986) Reduced fecundity of Hymenolepis nana due to thymus-dependent immunological responses in mice. International Journal for Parasitology, 16, 81–85.CrossRefGoogle ScholarPubMed
Mitchell, G. F. (1979) Responses to infection with metazoan and protozoan parasites in mice. Advances in immunology, 28, 451–511.CrossRefGoogle ScholarPubMed
Mitchell, G. F. (1982) The nude mouse in immunoparasitology. In: The Nude Mouse in Experimental Clinical Research II (editors. Fogh, J. & Giovanella, B. C.) pp. 1021–1059.Google Scholar
Ogilvie, B. M. & Parrott, D. M. (1977) The immunological consequences of nematode infection. In: Immunology of the Gut (editors. Porter, R. & Knight, J.) pp. 183–201. Elsevier: Amsterdam.Google Scholar
Rose, M. E., Ogilvie, B. M., Hesketh, P. & Festing, M. F. W. (1979) Failure of nude (athymic) rats to become resistant to reinfeciton with the interstinal coccidian parasiste Eimeria nieschulzi or the nematode Nippostrongylus brasiliensis. Parasite Immunology, 1, 125–132.CrossRefGoogle ScholarPubMed
Shorb, D. A. (1933) Host-parasite relations of Hymenolepis fraterna in the rat and mouse. American Journal of Hygiene, 18, 74–113.Google Scholar
Stevens, D. P., Frank, D. M. & Mahmoud, A. A. F. (1978) Thymus dependency of host resistance to Giradia muris infection: Studies in nude mice. Journal of Immunology, 120, 680–682.CrossRefGoogle Scholar
Wakelin, D. (1978) Immunity to intestinal parasites. Nature. 273, 617–620.CrossRefGoogle ScholarPubMed
Weinmann, C. J. (1964) Host resistance to Hymenolepis nana. II. Specificity of resistance to reinfection in th direct cycle. Experimental Parasitology. 15, 514–526.CrossRefGoogle ScholarPubMed