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Biological role of excretory–secretory proteins in endemic parasites of Latin America and the Caribbean

Published online by Cambridge University Press:  16 May 2019

S. Gomez-Fuentes ,
V. Morales-Ruiz ,
D. López-Recinos ,
A. Guevara-Salinas ,
A. Arce-Sillas ,
J.F. Rodríguez ,
C. Parada-Colin  and
L. Adalid-Peralta Open the ORCID record for L. Adalid-Peralta [Opens in a new window]
S. Gomez-Fuentes
Affiliation:
Unidad Periférica para el estudio de la Neuroinflamación en patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, 14269 Mexico City, Mexico
V. Morales-Ruiz
Affiliation:
Unidad Periférica para el estudio de la Neuroinflamación en patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, 14269 Mexico City, Mexico
D. López-Recinos
Affiliation:
Unidad Periférica para el estudio de la Neuroinflamación en patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, 14269 Mexico City, Mexico
A. Guevara-Salinas
Affiliation:
Unidad Periférica para el estudio de la Neuroinflamación en patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, 14269 Mexico City, Mexico
A. Arce-Sillas
Affiliation:
Unidad Periférica para el estudio de la Neuroinflamación en patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, 14269 Mexico City, Mexico
J.F. Rodríguez
Affiliation:
Unidad Periférica para el estudio de la Neuroinflamación en patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, 14269 Mexico City, Mexico
C. Parada-Colin
Affiliation:
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico
L. Adalid-Peralta*
Affiliation:
Unidad Periférica para el estudio de la Neuroinflamación en patologías Neurológicas del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, 14269 Mexico City, Mexico Instituto Nacional de Neurología y Neurocirugía, 14269 Mexico City, Mexico
*
Author for correspondence: L. Adalid-Peralta, E-mail: [email protected]
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Abstract

Neglected tropical diseases (NTDs) share certain traits: they are parasitic infections, prevailing in tropical environments and affecting marginalized sectors of the population. Six NTDs – ascariasis, cysticercosis, echinococcosis, hookworm infection, onchocerciasis and trichuriasis – all of them endemic in Latin America and the Caribbean (LAC), are analysed in this work. This review aims to discuss key information on the function of excretory/secretory (E/S) proteins from these parasites in their infectivity, pathogeny and diagnosis. The modulation of the host immune system to favour the permanence and survival of the parasite is also discussed. An updated knowledge on the function of E/S molecules in endemic parasitoses in LAC may lead to new approaches for the clinical management and diagnosis of these diseases. In turn, this could allow us to optimize their treatment and make it more affordable – a relevant goal given the economic constraints that the region is facing.

Keywords

Parasitesneglected tropical diseasesLatin Americaexcretion-secretion proteins
Type
Review Article
Information
Journal of Helminthology , Volume 94 , 2020 , e53
Copyright
Copyright © Cambridge University Press 2019 

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