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Association of Strongyloides stercoralis infection with the development of diabetes mellitus: a meta-analysis

Published online by Cambridge University Press:  20 December 2024

R.E. Tiongco Open the ORCID record for R.E. Tiongco [Opens in a new window] ,
J.A. Flores ,
E.J. Castro ,
S.A. Dayrit ,
M.J. Dominguez ,
E. Manahan  and
M.R. Pineda-Cortel
R.E. Tiongco*
Affiliation:
Department of Medical Technology, School of Health Sciences, UST General Santos, General Santos City 9500, Philippines
J.A. Flores
Affiliation:
Department of Medical Technology, College of Allied Medical Professions, Angeles University Foundation, Angeles City 2009, Philippines
E.J. Castro
Affiliation:
Department of Medical Technology, College of Allied Medical Professions, Angeles University Foundation, Angeles City 2009, Philippines
S.A. Dayrit
Affiliation:
Department of Medical Technology, College of Allied Medical Professions, Angeles University Foundation, Angeles City 2009, Philippines
M.J. Dominguez
Affiliation:
School of Medicine, Angeles University Foundation, Angeles City 2009, Philippines
E. Manahan
Affiliation:
Department of Medical Technology, School of Health Sciences, UST General Santos, General Santos City 9500, Philippines Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, Philippines
M.R. Pineda-Cortel
Affiliation:
Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, Philippines Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1008, Philippines
*
Corresponding author: R.E. Tiongco; Email: [email protected]
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Abstract

Previous studies have shown that helminth infection protects against the development of diabetes mellitus (DM), possibly related to the hygiene hypothesis. However, studies involving Stronglyoides stercoralis and its possible association with DM are scarce and have shown contradicting results, prompting us to perform this meta-analysis to obtain more precise estimates. Related studies were searched from PubMed, Google Scholar, Science Direct, and Cochrane Library until 1 August 2024. Data on the occurrence of DM in patients positive and negative for S. stercoralis were obtained. All analyses were done using Review Manager 5.4. The initial search yielded a total of 1725 studies, and after thorough screening and exclusion, only five articles involving 2106 participants (536 cases and 1570 controls) were included in the meta-analysis. Heterogeneity was assessed, and outlier studies were excluded using a funnel plot. Results showed a significant association of S. stercoralis infection with DM, suggesting that those with the infection are less likely to develop DM. Overall, the results suggest that S. stercoralis infection may decrease the likelihood of developing DM, potentially supporting the hygiene hypothesis.

Keywords

Strongyloides stercoralisdiabetes mellitusmeta-analysis
Type
Research Paper
Information
Journal of Helminthology , Volume 98 , 2024 , e86
Copyright
© The Author(s), 2024. Published by Cambridge University Press

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