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The anthelmintic effects of a new compound “E” (Friedheim) on Onchocerca gutturosa in the cow—a possible tertiary screening system for drug action against O. volvulus in man

Published online by Cambridge University Press:  05 June 2009

D. A. Denham  and
P. Mellor
D. A. Denham
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
P. Mellor
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
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Abstract

Three cows were treated with different levels of compound “E” which is known to have strong filaricidal activity. In all three animals the number of microfilariae of Onchocerca gutturosa declined after treatment. At autopsy most of the adult worms found were dead and in those still living embryogenesis appeared to have ceased.

It is concluded that, despite the disadvantages, this system represents a possible way of assessing onchocercicidal activity before undertaking human trials.

Type
Research Article
Information
Journal of Helminthology , Volume 50 , Issue 1 , March 1976 , pp. 49 - 52
Copyright
Copyright © Cambridge University Press 1976

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References

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