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Studies with Methyridine and Trichinella spiralis 2. The use of the drug to study the rate of larval production in mice

Published online by Cambridge University Press:  05 June 2009

D. A. Denham
Affiliation:
The London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1, England
A. R. Martinez
Affiliation:
Facultad de Veterinaria, León, Spain

Extract

It has not been easy to study the rate at which female Trichinella spiralis produce their offspring. Phillipson and Kershaw (1961) described a method of repeatedly grinding and washing infected muscle to collect immature larvae so that one could determine the number of larvae born by the time the animal was killed but their method is unsuitable for dealing with the large number of animals that would be needed for a thorough study of this aspect of the infection. We have sought a method of studying this important factor in the host-parasite relationship.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1970

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References

Campbell, W. C. and Cuckler, A. C, 1968.—“Comparative studies on the chemotherapy of experimental trichinosis in mice”.Z. Tropenmed. Parasit., 18, 408417.Google Scholar
Denham, D. A., 1965.—“Studies With Methyridine and Trichinella spiralis 1. Effect upon the intestinal phase in mice”.Expl Parasit., 17, 1014.CrossRefGoogle ScholarPubMed
Denham, D. A., 1966.—“Immunity To Trichinella spiralis 1. The immunity produced by mice to the first four days of the infection”.Parasitology, 56, 323327.CrossRefGoogle Scholar
Denham, D. A., 1968.—“Immunity To Trichinella spiralis 3. The longevity of the intestinal phase of the infection in mice”.J. Helminth., 42, 257–268.CrossRefGoogle ScholarPubMed
Janitschke, B., 1962.—“Untersuchungen an Meerschweinchen fiber die Wirkung von Promintic und Ruelene auf Larven von Trichinella spiralis und Toxocara canis”. 45 pp. Dissertation Free University of Berlin.Google Scholar
Larsh, J. E., 1963.—“Experimental Trichiniasis”.In Advances in Parasitology, 1,213282.CrossRefGoogle ScholarPubMed
Martinez, A. R., 1965.—“Investigaciones sobre la cficacia de la methiridina y del thiabendazole frente a Trichinella spiralis (Owen, 1835)-Railliet, 1895”.Thesis in An. Fac. Vet. Ledn. 11, 127220.Google Scholar
Matoff, K., 1943.—“Altersimmunitat Und parenteral erzeugte Muskcltrichinel-lose beim Hunde”.Zentbl. Bakt. Parasitkde 150, 328336.Google Scholar
Phillipson, R. F. and Kershaw, W. E., 1961.—“The production, deposition and growth of the larvae of Trichinella spiralis and their significance in the chemotherapy of the infection. 2. Production and deposition of larvae”.Ann. trop. Med. Parasit., 55, 231234.CrossRefGoogle Scholar
Schanzel, H. and Hegerova, E., 1963.—“VUV methyridin na Trichinella spiralis un bflych mySf”. Ada universltatis agriculturae, Brno, 11, 501506.Google Scholar
Schanzel, H. and Hegerova, E., 1964.—“The use of methyridine against the intestinal trichinellosis in white mice”. Ada universltatis agriculturae, Brno, 12, 385388.Google Scholar
Schanzel, H. and Hegerova, E., 1964 a.—“Einfluss von Methyridin auf die Muskellarven von Trichinella spiralis bei kunstlich invadierten Mausen”.Ange. Parasit., 5, 103166.Google Scholar
SCHOOP, G.. and Lamina, J. 1965.—“Die trichinozide Wirkung von Methyridin”.Dt. tierarztl. Wschr., 72, 319321.Google Scholar