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Resveratrol reduces oxidative damage and inflammation in mice infected with Trichinella spiralis

Published online by Cambridge University Press:  02 April 2020

D.I. Elgendy Open the ORCID record for D.I. Elgendy [Opens in a new window] ,
A.A. Othman ,
M.A. Hasby Saad ,
N.A. Soliman  and
S.E. Mwafy
D.I. Elgendy*
Affiliation:
Medical Parasitology Department, Faculty of Medicine, Tanta University, Egypt
A.A. Othman
Affiliation:
Medical Parasitology Department, Faculty of Medicine, Tanta University, Egypt
M.A. Hasby Saad
Affiliation:
Medical Parasitology Department, Faculty of Medicine, Tanta University, Egypt
N.A. Soliman
Affiliation:
Medical Biochemistry Department, Faculty of Medicine, Tanta University, Egypt
S.E. Mwafy
Affiliation:
Pathology Department, Faculty of Medicine, Tanta University, Egypt
*
Author for correspondence: D.I. Elgendy, E-mail: [email protected]
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Abstract

Trichinellosis is a serious food-borne zoonotic infection of cosmopolitan distribution. Currently, treatment for trichinellosis is far from ideal. Given the important role of oxidative stress and immune-mediated inflammation in the pathogenesis of trichinellosis, this study was designed to evaluate the possible protective effects of resveratrol (RSV) during the intestinal and muscular phases of Trichinella spiralis infection in mice. The oral administration of RSV at a dose of 20 mg/kg once daily for two weeks resulted in significant reductions in both adult and larval counts; significant improvements in the redox status of the small intestine and muscles; a significant reduction in interleukin 4, pentraxin 3 and vascular endothelial growth factor expression; and the mitigation of intestinal and muscular inflammation. In conclusion, this study identifies RSV as a promising agent for the treatment of experimental trichinellosis, and more studies in experimental animals and humans are worth consideration.

Keywords

Trichinella spiralisintestinal phasemuscular phaseresveratroloxidative stressIL-4PTX3VEGF
Type
Research Paper
Information
Journal of Helminthology , Volume 94 , 2020 , e140
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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