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Regulation of toxocariasis in mice selectively reared for high and low immune responses to Nematospiroides dubius

Published online by Cambridge University Press:  18 November 2009

P. J. Brindley ,
Paul Prociv ,
Catherine A. Creevey  and
I. J. East
P. J. Brindley
Affiliation:
Department of Parasitology, University of Queensland, St. Lucia 4067, Australia
Paul Prociv
Affiliation:
Department of Parasitology, University of Queensland, St. Lucia 4067, Australia
Catherine A. Creevey
Affiliation:
Department of Parasitology, University of Queensland, St. Lucia 4067, Australia
I. J. East
Affiliation:
Department of Parasitology, University of Queensland, St. Lucia 4067, Australia Long Pocket Laboratories, C.S.I.R.O. Division of Tropical Animal Science, Private Mail flag No. 3, Indooroopilly 4068, Australia
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Abstract

Test mice have been selectively reared for high (H) or low (L) immune responses to Nematospiroides dubius. After secondary infection with N. dubius, the L mice voided ten times as many eggs in their faeces as the II mice, and at necropsy, 71% versus 20% of the inoculum of N. dubius were recovered as adult worms from the L and II mice respectively. Furthermore, N. dubius were more fecund in the L than in H mice. High or low immune responsiveness was not restricted to N. dubius infection in these mice but was also observed during Toxocara canis infection. The migration of T canis larvae from gut via the liver to skeletal muscle and CNS was inhibited in H versus L mice. Many more larvae were recovered from the livers of II compared with L mice which was indicative of greater immunity in the H mice. The protective immune response in H compared with L mice to both N. dubius and T canis included pronounced cosinophilia and elevated antiparasite antibody titres.

Type
Research Article
Information
Journal of Helminthology , Volume 59 , Issue 2 , June 1985 , pp. 157 - 166
Copyright
Copyright © Cambridge University Press 1985

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