Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-03T05:29:37.288Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunological Studies on Experimental Infection of Guineapigs and Rabbits with Ascaris suum Goeze, 1782. I.—The Minimum Lethal Dose (M.L.D.) and the Minimum Immunizing Dose (M.I.D.) of Ascaris Eggs in Guineapigs*

Published online by Cambridge University Press:  18 November 2009

L. F. Taffs
L. F. Taffs
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Cambridge**
Get access Rights & Permissions [Opens in a new window]

Extract

Guineapigs infected with a lethal dose of Ascaris eggs died between the fifth and tenth day of infection. The M.L.D. was found to be 20,000 eggs. The clinical symptoms and the macroscopic lesions in the liver and lung are described. Infected guineapigs developed an active acquired immunity and repeated infection conferred a high degree of resistance on animals which were subsequently reinfected. Resistance was manifested by the survival of the host following a lethal dose of eggs, and by an inhibition of larval migration. (Less haemorrhage was found in the lung, and fewer larvae were recovered from the lungs and tracheae, after reinfection than following one infection).

The M.I.D. against a reinfective lethal dose 18 days after infection was 500 eggs. The smallest immunizing dose required to give resistance to a challenge 51 days later was 10,000 eggs. This suggests that the resistance manifested at three weeks is greater than that shown after seven weeks, i.e. there is a waning of the immunity.

Type
Research Papers
Information
Journal of Helminthology , Volume 38 , Issue 3-4 , December 1964 , pp. 303 - 314
Copyright
Copyright © Cambridge University Press 1964

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baudet, E. A. R. F., 1941.—“Über die Resistcnz des Mecrschweinchens gegenüber weiderholten Infcktionen mit Ascaris lumbricoides vom Schwein.” Z. InfekiKr. Haustiere, 58, 79–93.Google Scholar
Fallis, A. M., 1942.—“Resistance to Ascaris himbricoides L. in guinea pigs and the eosinophilia associated with infection.” J. Parasit., 28, (Suppl.), 21.Google Scholar
Fallis, A. M., 1942.—“Resistance to Ascaris lumbricoides L. infection as demonstrated experimentally in guinea pigs.” Canad. J. publ. Hlth., 35, 90.Google Scholar
Fallis, A. M., 1948.—“Ascaris lumbricoides infection in guinea pigs with special reference to eosinophilia and resistance.” Canad. J. Res., 26, 307–327.CrossRefGoogle ScholarPubMed
Kerr, K. B., 1938.—“The cellular response in acquired resistance in guinea pigs to an infection with pig Ascaris.” Amer. J. Hyg., 27, 28–51.Google Scholar
Matsushima, M., 1934.—“Experimental studies on the resistance against repeated infection of Ascaris.” Keiô Igaku, Tokyo, 14, 1119–1134.Google Scholar
Sprent, J. F. A. and Chen, H. H., 1949.—“Immunological studies in mice infected with the larvae of Ascaris lumbricoides. I. Criteria of immunity and immunizing effect of isolated worm tissues.” J. infect. Dis., 84, 111–124.CrossRefGoogle ScholarPubMed
Stewart, F. H., 1916.—“Further experiments on Ascaris infection.” Brit. vied. J., 2, 486–488.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1960.—“Immunization of guineapigs against Ascaris suum.” J. Helminth., 34, 347–348.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1961a.—“The passive transfer of immunity in guineapigs infected with the nematode Ascaris suum.” J. Helminth., 35, 315–318.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1961b.—“Immunological studies on experimental infection of pigs with Ascaris suum Goeze, 1782. I. An introduction with a review of the literature and the demonstration of complement-fixing antibodies in the serum.” J. Helminth., 35, 319–344.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1961c.—“The in vitro action of immune pig serum on second-and third-stage Ascaris suum larvae.” Parasitology, 51, 327–334.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1962.—“Immunological studies on the Ascaris of man and pig.” Parasitology., 52, 4P—5P.Google Scholar
Taffs, L. F., 1963.—“Immunological studies on experimental infection of pigs with Ascaris suum Goeze, 1782. II. The use of the conglutinating complement absorption test for the demonstraton of Ascaris antibody.” J. Helminth., 37, 369–380.CrossRefGoogle Scholar
Taffs, L. F., 1964a.—“Immunological studies on experimental infection of pigs with Ascaris suum Goeze, 1782. III. The antibody response and acquired immunity.” J. Helminth., 38, 129–150.CrossRefGoogle ScholarPubMed
Taffs, L. F., 1964b.—“Immunological studies on experimental infection of pigs with Ascaris suum Goeze, 1782. III. The primary antibody response”. J. Helminth., 38, 151–158.CrossRefGoogle Scholar
Taffs, L. F., 1964c.—“Immunological studies on experimental infection of pigs with Ascaris suum Goeze, 1782. V. The antibody response to the oral administration of third-and fourth-stage larvae.” J. Helminth., 38, 159–170.CrossRefGoogle Scholar
Wagner, O., 1933.—“Immunisierungsversuche bie experimenteller Askaris-Infektion der Maus.” Z. ImmunForsch., 78, 372–382.Google Scholar
Yoshida, S., 1919.—“On the development of Ascaris lumbricoides L.” J. Parasit., 5, 105–115.CrossRefGoogle Scholar