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Effect of ivermectin on infection with gastro-intestinal nematodes in Sierra Leone

Published online by Cambridge University Press:  05 June 2009

J.M. Behnke ,
D.I. Pritchard ,
D. Wakelin ,
J.R. Park ,
A.M. McNicholas  and
F.S. Gilbert
J.M. Behnke
Affiliation:
MRC Experimental Parasitology Research Group, Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD, UK
D.I. Pritchard
Affiliation:
MRC Experimental Parasitology Research Group, Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD, UK
D. Wakelin
Affiliation:
MRC Experimental Parasitology Research Group, Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD, UK
J.R. Park
Affiliation:
MRC Experimental Parasitology Research Group, Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD, UK
A.M. McNicholas
Affiliation:
MRC Laboratories, P.O. Box 81, Bo, Sierra Leone
F.S. Gilbert
Affiliation:
Behaviour and Ecology Research Group, Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD, UK
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Abstract

Levels of intestinal nematode infections were assessed six months after a two year trial of ivermectin for efficacy against onchocerciasis had ended. In the trial the inhabitants of six villages in Sierra Leone were offered treatment with ivermectin or placebo at six monthly intervals for four rounds in total. Quantitative faecal egg counts were carried out on stool samples provided by 202 subjects, all of whom had received all four rounds of treatment, in two of the villages (Dodo and Mogibisi). These data were analysed by a novel procedure in which a 3-way ANOVA with negative binomial errors enabled village and host gender influences on the outcome of treatment to be identified. Necator americanus was the most common species showing an overall prevalence of 90% but a higher intensity in Mogibisi relative to Dodo, particularly among male subjects. Neither prevalence nor intensity of infection were altered in ivermectin-treated compared with placebo-treated subjects. Trichuris trichiura was the least common species with a prevalence of 15%. It was concluded that there was no significant protection from infection with this species among the ivermectin relative to the placebo-treated subjects. Ascaris lumbricoides, with an overall prevalence of 39%, was more common among female (50%) compared with male (27%) villagers. Prevalence was not significantly affected by ivermectin but the intensity of infection declined by 91.3% in Dodo whilst in Mogibisi intensity was only reduced by 14.6%. The results indicate that the long-term benefits of treatment of necatoriasis and trichuriasis with ivermectin are likely to be minimal whilst those of ascariasis will depend on the individual characteristics of local communities and may differ quite markedly within a limited geographical area. Possible explanations for the discrepancy in efficacy between villages are considered.

Type
Research Papers
Information
Journal of Helminthology , Volume 68 , Issue 3 , September 1994 , pp. 187 - 195
Copyright
Copyright © Cambridge University Press 1994

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References

Behnke, J.M., Rose, R. & Garside, P. (1993) Sensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus. International Journal for Parasitology 23, 945–952.Google Scholar
Benz, G.W., Roncalli, R.A. & Gross, S.J. (1989) Use of ivermectin in cattle, sheep, goats and swine. pp. 215–229 in Campbell, W.C. (Ed.) Ivermectin and abamectin. New York, Springer-Verlag.Google Scholar
Bundy, D.A.P. (1990) Is the hookworm just another geohelminth? pp. 147–164in Schad, G.A. & Warren, K.S. (Eds) Hookworm disease: current status and new directions. London, Taylor & Francis.Google Scholar
Bundy, D.A.P. & Blumenthal, U.J. (1990) Human behaviour and the epidemiology of helminth infections: the role of behaviour in exposure to infection. pp. 264–289in Barnard, C.J. & Behnke, J.M. (Eds) Parasitism and host behaviour. London, Taylor & Francis.Google Scholar
Bundy, D.A.P., Thompson, D. E., Golden, M.H.N., Cooper, E.S., Anderson, R.M. & Harland, P.S.E. (1985) Population distribution of Trichuris trichiura in a community of Jamaican children. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 232–237.Google Scholar
Campbell, W.C. (1985) Ivermectin: an update. Parasitology Today 1, 10–16.Google Scholar
Keymer, A. & Pagel, M. (1990) Predisposition to helminth infection. PP. 177–209in Schad, G.A. & Warren, K.S. (Eds) Hookworm disease: current status and new directions. London, Taylor & Francis.Google Scholar
Pritchard, D.I., Quinnell, R.J., Slater, A.F.G., McKean, P.C., Dale, D.D.S., Raiko, A. & Keymer, A.E. (1990) Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens. Parasitology 100, 317–326.Google Scholar
Quinnell, R.J., Slater, A.F.G., Tighe, P.J., Walsh, E.A., Keymer, A.E. & Pritchard, D.I. (1993) Reinfection with hookworm after chemotherapy in Papua New Guinea. Parasitology 106, 379–385.Google Scholar
Richard-Lenoble, D., Kombila, M., Rupp, E.A., Pappayliou, E.S., Gaxotte, P., Nguiri, C. & Aziz, M.A. (1988) Ivermectin in loiasis and concurrent O. volvulus and M. perstans infections. American Journal of Tropical Medicine and Hygiene 39, 480–483.Google Scholar
Seo, B.S., Cho, S.Y., Chai, J.Y. & Hong, S.T. (1980) Comparative efficacy of various internal mass treatment on Ascaris lumbricoides infection in Korea. Korean Journal of Parasitology 18, 145–151.Google Scholar
Sokal, R.R. & Rohlf, F.J. (1981) Biometry. 2nd edn.San Francisco, Freeman & Co.Google Scholar
Whitworth, J.A.G., Morgan, D., Maude, G.H., McNicholas, A.M. & Taylor, D.W. (1991) A field study of the effect of ivermectin on intestinal helminths in man. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 232–234.CrossRefGoogle ScholarPubMed
World Health Organization (1963) CCTA/WHO African conference on ancylostomiasis,Brazzaville22–29 August 1961. Technical Report Series No. 225.Google Scholar