Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-08T00:10:31.875Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of cyclosporin A on the course of Paragonimus miyazakii infection in rats

Published online by Cambridge University Press:  05 June 2009

Yoshihisa Hashiguchi  and
Yoshisuke Okamura
Yoshihisa Hashiguchi
Affiliation:
Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781–51, Japan
Yoshisuke Okamura
Affiliation:
Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781–51, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

The effect of the immunomodulatory fungal metabolite cyclosporin A (CyA) on the course of Paragonimus miyazakii infection in rats was studied. Administration of CyA 15 to 19 days post-infection resulted in a significantly lower recovery rate of worms and cyst formation in the host's lungs than in controls. Administration of CyA − 1 to + 3 days post-infection enhanced the growth and maturation of P. miyazakii, expressed as weight of worms and the number of worms with eggs in uteri with respect to control values. This study shows that administration of CyA to rats affects the host-parasite relationship, depending on the time of administration of the drug.

Keywords

Paragonimus miyazakiiratcyclosporin Ainfection course
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 3 , September 1988 , pp. 251 - 256
Copyright
Copyright © Cambridge University Press 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Behforouz, N. C., Wenger, C. D. & Mathison, B. A. (1986) Prophylactic treatment of BALB/c mice with cyclosporine A and its analog B-5–49 enhances resistance to Leishmania major. Journal of Immunology, 136, 3067–3075.CrossRefGoogle ScholarPubMed
Belosevic, M., Faubert, G. M. & Maclean, J. D. (1986) The effects of cyclosporin A on the course of infection with Giardia muris in mice. American Journal of Tropical Medicine and Hygiene, 35, 496–500.CrossRefGoogle ScholarPubMed
Beveridge, T. (1982) Pharmacokinetics and metabolism of cyclosporin A. p. 35–44. In: Cyclosporin A, editor White, D. J.Amsterdam: Elsevier Biomedical Press.Google ScholarPubMed
Borel, J. F., Feurer, C., Gubler, H. V. & Stahelin, H. (1976) Biological effects of cyclosporin A: a new antilymphocytic agent. Agents and Actions, 6, 468–475.CrossRefGoogle ScholarPubMed
Bout, D., Deslee., D. & Capron, A. (1984a) Protection against schistosomiasis produced by cyclosporin A. American Journal of Tropical Medicine and Hygiene, 78, 670–671.CrossRefGoogle Scholar
Bout, D., Deslee, D. & Capron, A. (1986) Antischistosomal effect of cyclosporin A: cure and prevention of mouse and rat schistosomiasis mansoni. Infection and Immunity, 52, 823–827.CrossRefGoogle ScholarPubMed
Bout, D., Haque, A. & Capron, A. (1984b) Filaricidal effects of cyclosporin A against Dipetalonema viteae in Mastomys natalensis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 78, 670–671.CrossRefGoogle ScholarPubMed
Bueding, E., Hawkins, J. & Cha, Y. N. (1981) Antischistosomal effects of cyclosporin A. Agents and Actions, 11, 380–383.CrossRefGoogle ScholarPubMed
Hashiguchi, Y. & Agatsuma, T. (1981) Studies on the distribution of Paragonimus miyazakii in Shikoku, Japan. 2. Examination in eastern Shikoku and Is. Awaji. Japanese Journal of Parasitology, 30, 295–299.Google Scholar
Hashiguchi, Y. & Hirai, H. (1977) Influence of immunosuppressants on the establishment of Paragonimus miyazakii in albino rats. Journal of Helminthology, 51, 87–94.CrossRefGoogle ScholarPubMed
Kierszenbaum, F., Gottlieb, C. A. & Budzko, D. B. (1983) Exacerbation of Trypanosoma cruzi infection in mice treated with the immunoregulatory agent cyclosporin A. Tropenmedizin und Parasitologie, 34, 4–6.Google ScholarPubMed
Mack, D. G. & Mcleod, R. (1984) New micromethod to study the effect of antimicrobial agents on Toxoplasma gondii: comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin, metronidazole, and cyclosporin A. Antimicrobial Agents Chemotherapy, 26, 26–30.CrossRefGoogle Scholar
Mccabe, R. E., Remington, J. S. & Araujo, F. G. (1985) In vivo and in vitro effects of cyclosporin A on Trypanosoma cruzi. American Journal of Tropical Medicine and Hygiene, 34, 861–865.CrossRefGoogle ScholarPubMed
Nickell, S. P., Scheibel, L. W. & Cole, G. A. (1982) Inhibition by cyclosporin A of rodent malaria in vivo and human malaria in vitro. Infection and Immunity, 37, 1093–1100.CrossRefGoogle ScholarPubMed
Nilsson, L. A., Lindblad, R., Olling, S. & Ouchterlony, O. (1985) The effect of cyclosporin A on the course of murine infection by Schistosoma mansoni. Parasite Immunology, 7, 19–27.CrossRefGoogle ScholarPubMed
Solbach, W., Forberg, K., Kammerer, E., Bogdan., C. & Rollinghoff, M. (1986) Suppressive effect of cyclosporin A on the development of Leishmania tropica-induced lesions in genetically susceptible BALB/c mice. Journal of Immunology, 137, 702–707.CrossRefGoogle ScholarPubMed
Tada, I. (1967) The effect of worm burden and cortisone on the Paragonimus infection in albino rats. Japanese Journal of Parasitology, 16, 51–57.Google Scholar
Thommen-Scott, K. (1981) Antimalarial activity of cyclosporin A. Agents and Actions, 11, 770–773.CrossRefGoogle ScholarPubMed