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Effect of antibiotics on protein synthesis in filarial parasites

Published online by Cambridge University Press:  05 June 2009

J. H. Wani  and
V. M. L. Srivastava
J. H. Wani
Affiliation:
Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, U.P., India
V. M. L. Srivastava
Affiliation:
Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, U.P., India
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Abstract

Acanthocheilonema viteae, Litomosoides carinii and Setaria cervi were found to actively synthesize proteins in vitro. Different centrifugation fractions and their TCA-precipitable fractions were assessed for the distribution of newly synthesized proteins. Penicillin and streptomycin inhibited the process in A. viteae. The synthesis in S. cervi was susceptible to puromycin, chloramphenicol, cycloheximide, neomycin and polymyxin B. The process in L. carinii was strongly blocked by puromycin while chloramphenicol had no significant effect.

Keywords

Acanthocheilonema viteaeLitomosoides cariniiSetaria cerviprotein synthesisantibioticsNematodafilariidschemotherapy
Type
Research Papers
Information
Journal of Helminthology , Volume 67 , Issue 4 , December 1993 , pp. 265 - 270
Copyright
Copyright © Cambridge University Press 1993

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