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Echinococcus granulosus: development of resistance to albendazole in an animal model

Published online by Cambridge University Press:  05 June 2009

D. L. Morris  and
D. H. Taylor
D. L. Morris
Affiliation:
Department of Surgery, University Hospital, Nottingham, UK
D. H. Taylor
Affiliation:
Department of Surgery, University Hospital, Nottingham, UK
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Abstract

Gerbils with well developed peritoneal cysts of Echinococcus granulosus were randomized to albendazole 50 mg/kg/day or untreated control. Treated animals had less disease at post mortem after 3 months of treatment. Cysts were then taken from both albendazole-treated and control animals and cultured in vitro either with or without albendazole sulphoxide (Alb Sx) 500 μg/L for 14 days. Viability of cysts was then established by implantation of whole cysts into gerbils. Whilst naive cysts were affected by Alb Sx (only 2 cysts developed/gerbil) cysts from animals treated with albendazole were not sensitive to further therapy (6.4 cysts/gerbil).

Keywords

Echinococcus granulosusgerbilalbendazoledrug resistance
Type
Research Article
Information
Journal of Helminthology , Volume 64 , Issue 2 , June 1990 , pp. 171 - 174
Copyright
Copyright © Cambridge University Press 1990

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References

REFERENCES

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