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The ability of single sex infections of Schistosoma japonicum to induce resistance to reinfection in mice

Published online by Cambridge University Press:  05 June 2009

N. A. Moloney ,
P. Hinchcliffe  and
G. Webbe
N. A. Moloney
Affiliation:
The ability of single sex infections of Schistosoma japonicum to induce resistance to reinfection in mice
P. Hinchcliffe
Affiliation:
The ability of single sex infections of Schistosoma japonicum to induce resistance to reinfection in mice
G. Webbe
Affiliation:
The ability of single sex infections of Schistosoma japonicum to induce resistance to reinfection in mice
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Abstract

In four experiments, mice harbouring an average 50, 76 or over 200 Schistosoma japonicum female worms were not resistant when challenged six to eight weeks after infection. The female worms from these single sex infections were stunted and immature (average length 4–6 mm) and induced no overt pathology in the host. Male worm burdens of 60, 135 or 140 also induced little or no resistance to challenge in the host. The males from these single sex infections were fully grown for their age (average length 9 mm) and burdens of 135 or 140 induced distended hepatic portal veins and marked deposition of pigment in the livers of infected mice.

Keywords

Schistosoma japonicummouseresistancesingle sex infections
Type
Research Article
Information
Journal of Helminthology , Volume 60 , Issue 3 , September 1986 , pp. 250 - 254
Copyright
Copyright © Cambridge University Press 1986

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References

REFERENCES

Bickle, Q., Bain, J., Mcgregor, A. & Doenhoff, M. (1979) Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. III. The failure of primary infections with cercariae of one sex to induce resistance to reinfection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 73, 37–41.Google Scholar
Dean, D. A. (1983) A review. Schistosoma and related genera: Acquired resistance in mice. Experimental Parasitology, 55, 1–104.Google Scholar
Dean, D. A., Minard, P., Murrell, K. D. & Vannier, W.E. (1978) Resistance of mice to secondary infection with Schistosoma mansoni. II. Evidence for a correlation between egg deposition and worm elimination. American Journal of Tropical Medicine and Hygiene, 27, 957–956.Google Scholar
Garcia, E. G., Mitchell, G. F., Espinas, F. J. M.,Tapales, F. P., Quicho, L. P. & Tiu, W. U. (1984) Further studies on resistance to reinfection with Schistosoma japonicum in the mouse. Asian Pacific Journal of Allergy and Immunology, 2, 27.Google Scholar
Garcia, E. G., Mitchell, G. F., Tiu, W. U., Tapales, F. P. & Valdez, C.A. (1983) Resistance to reinfection with Schistosoma japonicum in the mouse. South East Asian Journal of Tropical Medicine and Public Health, 14, 133–140.Google Scholar
Harrison, R. A., Bickle, Q. & Doenhoff, M. (1982) Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. Evidence that the mechanisms which mediate resistance during early patent infections may lack immunological specificity. Parasitology, 84, 93–110.Google Scholar
Lin, S., Ritchie, L. S. & Hunter, G.W. (1954) Acquired immunologic resistance against Schistosoma japonicum. Journal of Parasitology, 40 (Suppl.), 42.Google Scholar
Moloney, N. A., Bickle, Q. D. & Webbe, G. (1985) The induction of specific immunity against Schistosoma japonicum by the exposure of mice to ultra-violet attenuated cercariae. Parasitology, 90, 313–323.Google Scholar
Moloney, N. A. & Webbe, G. (1982) A rapid method for the infection of laboratory mice with Schistosoma Japonicum. Transactions of the Royal Society of Tropical Medicine and Hygiene, 76, 200–203.Google Scholar
Moloney, N. A. & Webbe, G. (1984) Factors affecting the acquisition of resistance to Schistosoma Japonicum in the mouse. II. Evidence that resistance to reinfection is not mediated by specific effector mechanisms. Parasitology, 89, 361–367.CrossRefGoogle Scholar
Moloney, N. A., Webbe, G. & Luty, A.J. (1984) Factors affecting the acquisition of resistance to Schistosoma japonicum in the mouse. I. The correlation between egg deposition and worm elimination. Parasitology, 89, 345–360.Google Scholar
Severinghaus, A. E. (1928) Sex studies in Schistosoma japonicum. Quarterly Journal of Microscopical Science, 71, 653–703.Google Scholar
Smithers, S. R. & Terry, R.J. (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology, 55, 695–700.Google Scholar
Vogel, H. (1941) Uber den Einfluss des Geschelechtspartners auf Wachstum und Entwicklung bei Bilharzia mansoni und Kreuzpaarungen zwischen verschiedenen Bilharzia-Arten. Zentralblatt für Parasitenkunde, 148, 78–96.Google Scholar
Wilson, R. A., Coulson, P. S. & Mchugh, S. M. (1983) A significant part of the ‘concomitant immunity’ of mice to Schistosoma mansoni is the consequence of a leaky hepatic portal system, not immune killing. Parasite Immunology, 5, 595–601.CrossRefGoogle Scholar