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Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields

Published online by Cambridge University Press:  22 June 2001

J. K. COMER ,
C. KLEINSTREUER  and
Z. ZHANG
J. K. COMER
Affiliation:
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USA
C. KLEINSTREUER
Affiliation:
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USA
Z. ZHANG
Affiliation:
Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, USA
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Abstract

The understanding and quantitative assessment of air flow fields and local micron-particle wall concentrations in tracheobronchial airways are very important for estimating the health risks of inhaled particulate pollutants, developing algebraic transfer functions of global lung deposition models used in dose-response analyses, and/or determining proper drug-aerosol delivery to target sites in the lung. In this paper (Part 1) the theory, model geometries, and air flow results are provided. In a companion paper (Part 2, Comer et al. 2001), the history of particle deposition patterns and comparisons with measured data sets are reported. Decoupling of the naturally dilute particle suspension makes it feasible to present the results in two parts.

Considering a Reynolds number range of 500 [les ] ReD [les ] 2000, it is assumed that the air flow is steady, incompressible and laminar and that the tubular double bifurcations, i.e. Weibel's generations G3–G5, are three-dimensional, rigid, and smooth with rounded as well as sharp carinal ridges for symmetric planar, and just rounded carinas for 90° non-planar configurations. The employed finite-volume code CFX (AEA Technology) and its user-enhanced FORTRAN programs were validated with experimental velocity data points for a single bifurcation. The resulting air flow structures are analysed for relatively low (ReD = 500) and high (ReD = 2000) Reynolds numbers. Sequential pressure drops due to viscous effects were calculated and compared, extending a method proposed by Pedley et al. (1977). Such detailed results for bifurcating lung airways are most useful in the development of global algebraic lung models.

Type
Research Article
Information
Journal of Fluid Mechanics , Volume 435 , 25 May 2001 , pp. 25 - 54
Copyright
© 2001 Cambridge University Press

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