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Prenatal and early-life predictors of atopy and allergic disease in Canadian children: results of the Family Atherosclerosis Monitoring In earLY life (FAMILY) Study

Published online by Cambridge University Press:  25 July 2016

T. Batool ,
P. L. Reece ,
K. M. Schulze ,
K. M. Morrison ,
S. A. Atkinson ,
S. S. Anand ,
K. K. Teo ,
J. A. Denburg ,
M. M. Cyr  and
the FAMILY Study Investigators
T. Batool*
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
P. L. Reece
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
K. M. Schulze
Affiliation:
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
K. M. Morrison
Affiliation:
Population Health Research Institute, McMaster University, Hamilton, ON, Canada Department of Pediatrics, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
S. A. Atkinson
Affiliation:
Department of Pediatrics, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada
S. S. Anand
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada Population Health Research Institute, McMaster University, Hamilton, ON, Canada Department of Clinical Epidemiology, McMaster University, Hamilton, ON, Canada
K. K. Teo
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada Population Health Research Institute, McMaster University, Hamilton, ON, Canada
J. A. Denburg
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
M. M. Cyr
Affiliation:
Department of Medicine, McMaster University, Hamilton, ON, Canada
the FAMILY Study Investigators
Affiliation:
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
*
*Address for correspondence: T. Batool, 105-300 Rossland Road East, Ajax, ON L1Z 0M1, Canada. (Email [email protected])
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Abstract

Prenatal and early-life environmental exposures play a key role in the development of atopy and allergic disease. The Family Atherosclerosis Monitoring In earLY life Study is a general, population-based Canadian birth cohort that prospectively evaluated prenatal and early-life traits and their association with atopy and/or allergic disease. The study population included 901 babies, 857 mothers and 530 fathers. Prenatal and postnatal risk factors were evaluated through questionnaires collected during the antenatal period and at 1 year. The end points of atopy and allergic diseases in infants were evaluated through questionnaires and skin prick testing. Key outcomes included atopy (24.5%), food allergy (17.5%), cow’s milk allergy (4.8%), wheezing (18.6%) and eczema (16%). The association between infant antibiotic exposure [odds ratio (OR): 2.04, 95% confidence interval (CI): 1.45–2.88] and increased atopy was noted in the multivariate analysis, whereas prenatal maternal exposure to dogs (OR: 0.60, 95% CI: 0.42–0.84) and acetaminophen (OR: 0.68, 95% CI: 0.51–0.92) was associated with decreased atopy. This population-based birth cohort in Canada demonstrated high rates of atopy, food allergy, wheezing and eczema. Several previously reported and some novel prenatal and postnatal exposures were associated with atopy and allergic diseases at 1 year of age.

Keywords

allergy/atopyhumannewborn childrenoutcome/systempregnancy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 7 , Issue 6: Themed Issue: Developmental Origins of Adult Mental Health and Illness , December 2016 , pp. 665 - 671
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016 

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