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Predictors of adults’ body mass index and the association with index child’s infant birth weight, in the Lifeways Cross-Generation Cohort Study of a thousand families in the Republic of Ireland

Published online by Cambridge University Press:  22 June 2017

S. McKey ,
M. Heinen ,
J. Mehegan ,
R. Somerville ,
H. Khalil ,
R. Segurado ,
C. Murrin ,
C. C. Kelleher  and
for the Lifeways Cross-Generation Cohort Study Steering Group
S. McKey
Affiliation:
HRB Centre for Diet and Health Research, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Ireland
M. Heinen
Affiliation:
HRB Centre for Diet and Health Research, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Ireland
J. Mehegan
Affiliation:
HRB Centre for Diet and Health Research, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Ireland
R. Somerville
Affiliation:
HRB Centre for Diet and Health Research, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Ireland
H. Khalil
Affiliation:
HRB Centre for Diet and Health Research, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Ireland
R. Segurado
Affiliation:
HRB Centre for Diet and Health Research, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Ireland
C. Murrin
Affiliation:
HRB Centre for Diet and Health Research, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Ireland
C. C. Kelleher*
Affiliation:
HRB Centre for Diet and Health Research, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Ireland
*
*Address for correspondence: C. C. Kelleher, School Public Health, Physiotherapy, Sports Sciences, University College Dublin, Woodview House, Belfield, Dublin 4, Dublin, Ireland. (Email: [email protected])
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Abstract

The Lifeways study is novel in having information on three generations of the same families. It is well established that infant birth weight (IBW) predicts individuals’ risk of adult chronic disease and more recently studies report cross-generation transmission of risk patterns. The aims of this analysis were to examine whether adults’ birth weights were associated with measures of own health status or social position and to relate adults’ birth weights to that of the index child’s IBW. Finally, we assessed whether birth weight of either adults or children was associated with adult body mass index (BMI) of parents and grandparents. We included 1075 children whose IBW was recorded at recruitment from hospital records and 2546 adult cohort members followed from 2001 until 2014. At baseline, a sub-group of 920 adults had reported own birth weight (RBW). Results showed male adults’ RBW were significantly higher than females’ (P=0.001). Mothers’ RBW was significantly correlated with IBW (r=0.178, P<0.001). In mixed effects linear models with BMI as the outcome variable, of all adults, and in sub-groups of adults with RBW and of mothers only, the IBW was associated with adult BMI adjusting for other predictors. Adults’ BMI was positively associated with age (P=0.013), index child’s IBW (P=0.001), gender (P<0.001) but not own RBW, adjusting for family identification number. When mothers were removed from the adult models however, IBW ceased to be associated with BMI, a final model showed RBW being associated with adult BMI (P=0.04). There are cross-generational associations in the Lifeways cohort, the maternal association being stronger.

Keywords

birth weightcohortcross-generationLifeways
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 6 , December 2017 , pp. 649 - 657
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

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Footnotes

†

S.M. and M.H. contributed equally to this analysis.

References

1. Barker, DJP, Osmond, C, Winter, PD, et al. Weight in infancy and death from ischaemic heart disease. Lancet. 1989; 334, 577–580.Google Scholar
2. Belbasis, L, Savvidou, MD, Kanu, C, et al. Birthweight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses. BMC Med. 2016; 14, 147.CrossRefGoogle ScholarPubMed
3. Rich-Edwards, JW, Colditz, GA, Stampfer, MJ, et al. Birthweight and the risk for type 2 diabetes mellitus in adult women. Ann Intern Med. 1999; 130(Pt 1), 278–284.Google Scholar
4. Rich-Edwards, JW, Kleinman, K, Michels, KB, et al. Longitudinal study of birthweight and adult body mass index in predicting risk of coronary heart disease and stroke in women. BMJ. 2005; 330, 1115.Google Scholar
5. Hales, CN, Barker, DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Int J Epidemiol. 2013; 42, 1215–1222.Google Scholar
6. Parsons, TJ, Power, C, Manor, O. Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study. BMJ. 2001; 323, 1331–1335.CrossRefGoogle ScholarPubMed
7. Curhan, GC, Willett, WC, Rimm, EB, et al. Birthweight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation. 1996; 94, 3246–3250.Google Scholar
8. O’Mahony, D, Fallon, UB, Hannon, F, et al. Lifeways The Lifeways Cross-Generation Study: design, recruitment and data management considerations. Ir Med J. 2007; 100(Suppl.), 3–6.Google Scholar
9. Kelleher, CC, Viljoen, K, Khalil, H, et al. Longitudinal follow-up of the relationship between dietary intake and growth and development in the Lifeways cross-generation cohort study 2001–2013. Proc Nutr Soc. 2014; 73, 118–131.Google Scholar
10. Kelly, GE, Murrin, C, Viljoen, K, et al. Body mass Index is associated with the maternal lines but height is heritable across family lines in the Lifeways cross-generation cohort. BMJ Open. 2014; 4, e005732.CrossRefGoogle ScholarPubMed
11. Shrivastava, A, Murrin, C, Sweeney, MR, et al. Familial intergenerational and maternal aggregation patterns in nutrient intakes in the Lifeways Cross-Generation Cohort Study. Public Health Nutr. 2013; 16, 1476–1486.Google Scholar
12. Murrin, C, Shrivastava, A, Kelleher, CC, et al. Maternal macronutrient intake during pregnancy and 5 years postpartum and associations with child weight status aged five. Eur J Clin Nutr. 2013; 67, 670–679.Google Scholar
13. Shiely, F, Perry, IJ, Lutomski, J, et al. Temporal trends in misclassification patterns of measured and self-report based body mass index categories – findings from three population surveys in Ireland. BMC Public Health. 2010; 10, 560.Google Scholar
14. Whincup, PH, Kaye, SJ, Owen, CG, et al. Birthweight and risk of type 2 diabetes: a systematic review. JAMA. 2008; 300, 2886–2897.Google Scholar
15. Cnattingius, S, Villamor, E, Lagerros, YT, et al. High birthweight and obesity – a vicious circle across generations. Int J Obes (Lond). 2012; 36, 1320–1324.Google Scholar
16. Durmuş, B, Arends, LR, Ay, L, et al. Parental anthropometrics, early growth and the risk of overweight in pre-school children: the Generation R Study. Pediatr Obes. 2013; 8, 339–350.Google Scholar
17. Manor, O, Koupil, I. Birthweight of infants and mortality in their parents and grandparents: the Uppsala Birth cohort Study. Int J Epidemiol. 2010; 39, 1264–1276.Google Scholar
18. Naess, O, Stoltenberg, C, Hoff, DA, et al. Cardiovascular mortality in relation to birthweight of children and grandchildren in 500,000 Norwegian families. Eur Heart J. 2013; 34, 3427–3436.Google Scholar
19. Kwok, MK, Leung, GM, Lam, TH, et al. Grandparental education, parental education and child height: evidence from Hong Kong’s Children of 1997 birth cohort. Ann Epidemiol. 2013; 23, 475–484.Google Scholar
20. Smith, GCS, Wood, AM, White, IR, et al. Birthweight and risk of cardiovascular disease in the maternal grandparents. Am J Epidemiol. 2010; 171, 736–744.Google Scholar
21. McCarron, P, Davey Smith, G, Hattersley, AT, et al. Type 2 diabetes in grandparents and birthweight in offspring and grandchildren in the ALSPAC study. J Epidemiol Community Health. 2004; 58, 517–522.Google Scholar
22. Crozier, SR, Inskip, HM, Godfrey, KM, et al. Weight gain in pregnancy and childhood body composition: findings from the Southampton Women’s Survey. Am J Clin Nutr. 2010; 91, 1745–1751.Google Scholar
23. Bhattacharya, S, McNeill, G, Raja, EA, et al. Maternal gestational weight gain and offspring’s risk of cardiovascular disease and mortality. Heart. 2016; 102, 1456–1463.Google Scholar
24. Reynolds, RM, Allan, KM, Raja, EA, et al. Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years. BMJ. 2013; 347, f4539.Google Scholar
25. Wells, JC. Worldwide variability in growth and its association with health: incorporating body composition, developmental plasticity, and intergenerational effects. Am J Hum Biol. 2017; Jan 22. https://doi.org/10.1002/ajhb.22954 [Epub ahead of print].Google Scholar
26. Richmond, RC, Timpson, NJ, Felix, JF, et al. Using genetic variation to explore the causal effect of maternal pregnancy adiposity on future offspring adiposity: a Mendelian Randomisation Study. PLoS Med. 2017; 14, e1002221.Google Scholar
27. Tyrrell, J, Richmond, RC, Palmer, TM, et al. Early Growth Genetics (EGG) Consortium. Genetic evidence for causal relationships between maternal obesity-related traits and birthweight. JAMA. 2016; 315, 1129–1140, Erratum in JAMA. 2016;315:1661.Google Scholar
28. Lunde, A, Melve, KK, Gjessing, HK, et al. Genetic and environmental influences on birth weight, birth length, head circumference, and gestational age by use of population-based parent-offspring data. Am J Epidemiol. 2007; 165, 734–741.Google Scholar
29. Emanuel, I, Filakti, H, Alberman, E, et al. Intergenerational studies of human birthweight from the 1958 birth cohort. 1. Evidence for a multigenerational effect. Br J Obstet Gynaecol. 1992; 99, 67–74.Google Scholar
30. Tehranifar, P, Liao, Y, Flom, JD, et al. Validity of self-reported birthweight by adult women: sociodemographic influences and implications for life-course studies. Am J Epidemiol. 2009; 170, 910–917.Google Scholar
31. Troy, LM, Michels, KB, Hunter, DJ, et al. Self-reported birthweight and history of having been breastfed among younger women: an assessment of validity. Int J Epidemiol. 1996; 25, 122–127.Google Scholar
32. Poulter, NR, Chang, CL, MacGregor, AJ, et al. Association between birthweight and adult blood pressure in twins: historical cohort study. BMJ.. 1999; 319, 1330–1333.Google Scholar
33. Shrivastava, A, Murrin, C, O’Brien, J, et al. Grandparental morbidity and mortality patterns are associated with infant birthweight in the Lifways cross-generation cohort study 2001–2010. J Dev Orig Health Dis. 2012; 3, 458–468.Google Scholar
34. Viljoen, K. Longitudinal follow-up of morbidity, healthcare utilisation and mortality patterns in the Lifeways cross-generation cohort study. Ph.D. Thesis, Health Sciences Library (vol. 1766), 2014. University College Dublin: Dublin.Google Scholar