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Ovine fetal renal development impacted by multiple fetuses and uterine space restriction

Published online by Cambridge University Press:  18 July 2013

K. M. Meyer-Gesch ,
M. Y. Sun ,
J. M. Koch ,
J. Ramadoss ,
S. E. Blohowiak ,
R. R. Magness  and
P. J. Kling
K. M. Meyer-Gesch
Affiliation:
Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA Animal Sciences, University of Wisconsin, Madison, WI 53715, USA Obstetrics and Gynecology, Perinatal Research Laboratory, University of Wisconsin, Madison, WI 53715, USA
M. Y. Sun
Affiliation:
Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA Obstetrics and Gynecology, Perinatal Research Laboratory, University of Wisconsin, Madison, WI 53715, USA
J. M. Koch
Affiliation:
Obstetrics and Gynecology, Perinatal Research Laboratory, University of Wisconsin, Madison, WI 53715, USA
J. Ramadoss
Affiliation:
Obstetrics and Gynecology, Perinatal Research Laboratory, University of Wisconsin, Madison, WI 53715, USA UTMB-Galveston, Galveston, TX, USA
S. E. Blohowiak
Affiliation:
Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA
R. R. Magness
Affiliation:
Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA Animal Sciences, University of Wisconsin, Madison, WI 53715, USA Obstetrics and Gynecology, Perinatal Research Laboratory, University of Wisconsin, Madison, WI 53715, USA
P. J. Kling*
Affiliation:
Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA
*
Address for correspondence: P. J. Kling, Department of Pediatrics, University of Wisconsin, 202 S. Park St., Neonatology Divsision, Madison 53715, USA. Email [email protected]
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Abstract

Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes impaired nephrogenesis and ultimately hypertension, but it is unknown whether IUGR caused by insufficient space for placental development seen in uterine anomalies and/or multifetal gestation exerts the same effects. Fetal renal development and metabolism were studied in an ovine space-restriction model by combining unilateral horn surgical ligation and/or multifetal gestation. Reduced placental attachment sites and placental weight per fetus defined space-restricted (USR) v. control nonrestricted (NSR) fetuses. Space-restricted fetuses exhibited evidence for decreased plasma volume, with higher hematocrit and plasma albumin at gestational day (GD) 120, followed by lower blood pO2, and higher osmolarity and creatinine at GD130, P < 0.05 for all. By combining treatments, fetal kidney weight relative to fetal weight was inversely related to both fetal weight and plasma creatinine levels, P < 0.05 for both. At GD130, space-restricted fetal kidney weights, cortical depths and glomerular generations were decreased, P < 0.05 for all. Space-restricted kidneys underwent an adaptive response by prolonging active nephrogenesis and increasing maculae densa number, P < 0.05 for both. The major renal adaptations in space-restricted IUGR fetuses included immaturity in both development and endocrine function, with evidence for impaired renal excretory function.

Keywords

IUGR, renal development, uterine space restriction
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 4 , Issue 5 , October 2013 , pp. 411 - 420
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2013 

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