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Maternal diet-induced obesity and offspring cardiovascular health

Published online by Cambridge University Press:  11 January 2013

H. L. Blackmore  and
S. E. Ozanne
H. L. Blackmore
Affiliation:
Level 4 Metabolic Research Laboratories, Institute of Metabolic Sciences, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
S. E. Ozanne*
Affiliation:
Level 4 Metabolic Research Laboratories, Institute of Metabolic Sciences, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
*
*Address for correspondence: Dr S. E. Ozanne, Level 4 Metabolic Research Laboratories, Institute of Metabolic Sciences, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0QQ, UK (Email [email protected])
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Abstract

It is widely recognized that environmental insults during adulthood including smoking, lack of exercise and a poor diet increases an individual's risk of cardiovascular disease (CVD). However, research initiated over the last two decades has highlighted that our risk of CVD can be programmed following adverse exposures during early development. Such adverse exposures may include, undernutrition, placental insufficiency, hypoxia, overnutrition and obesity. This review aims to address the current Western obesity crisis by addressing the long-term impact of maternal overnutrition and obesity on the offspring's future risk of CVD. Although current human studies have observed the presence of adverse CVD markers in children born to obese mothers, animal models have proved vital in understanding the underlying mechanisms involved. Mechanisms suggested to be involved in the programming of CVD in the offspring include increased oxidative stress, inflammation, lipotoxicity and epigenetics. CVD remains the greatest cause of death worldwide, therefore further understanding of the mechanisms mediating these effects is important in the development of intervention strategies.

Keywords

cardiovascular diseasedevelopmental programmingmaternal obesitymechanismsanimal models
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 4 , Issue 5 , October 2013 , pp. 338 - 347
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2013 

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