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Maternal and newborn infants amino acid concentrations in obese women born themselves with normal and small for gestational age birth weight

Published online by Cambridge University Press:  30 April 2015

P. B. Tsyvian ,
N. V. Bashmakova ,
O. P. Kovtun ,
L. V. Makarenko  and
L. A. Pestryaeva
P. B. Tsyvian*
Affiliation:
Mother and Child Care Research Institute, Russian Ministry of Public Health, Yekaterinburg, Russia Ural State Medical University, Yekaterinburg, Russia Institute of Immunology and Physiology, Ural branch of Russian Academy of Sciences Yekaterinburg, Russia
N. V. Bashmakova
Affiliation:
Mother and Child Care Research Institute, Russian Ministry of Public Health, Yekaterinburg, Russia
O. P. Kovtun
Affiliation:
Ural State Medical University, Yekaterinburg, Russia
L. V. Makarenko
Affiliation:
Mother and Child Care Research Institute, Russian Ministry of Public Health, Yekaterinburg, Russia
L. A. Pestryaeva
Affiliation:
Mother and Child Care Research Institute, Russian Ministry of Public Health, Yekaterinburg, Russia
*
*Address for correspondence: P. B. Tsyvian, Mother and Child Care Research Institute, Repin str 1, 620028, Yekaterinburg, Russia. (Email [email protected])
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Abstract

This study was undertaken to compare amino acid concentrations in maternal and newborn infants’ serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino acid concentrations were evaluated at the time of delivery in 28 normal pregnancies, 46 obese pregnant women with normal birth weight (Ob-AGA group) and 44 obese pregnant women born themselves SGA (Ob-SGA group). Mean birth weight of newborn infants in Ob-SGA group was significantly less than in normal and Ob-AGA groups. Cholesterol and lipoproteins were significantly elevated in obese women (more prominent in Ob-SGA group). Most amino acid concentrations and fetal–maternal amino acid gradients were significantly lower in Ob-SGA group. These data suggest significant changes in placental amino acid transport/synthetic function in obese women who were born themselves SGA.

Keywords

amino acidsmaternal obesitypregnancy
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 6 , Issue 4 , August 2015 , pp. 278 - 284
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

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