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The interleukins IL-6 and IL-1Ra: a mediating role in the associations between BMI and birth weight?

Published online by Cambridge University Press:  21 July 2010

C. M. Friis ,
K. F. Frøslie ,
J. Røislien ,
N. Voldner ,
K. Godang ,
T. Ueland ,
J. Bollerslev ,
M. B. Veierød  and
T. Henriksen
C. M. Friis*
Affiliation:
Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway Division of Obstetrics and Gynaecology, National Resource Centre for Women’s Health, Oslo University Hospital Rikshospitalet, Oslo, Norway
K. F. Frøslie
Affiliation:
Division of Obstetrics and Gynaecology, National Resource Centre for Women’s Health, Oslo University Hospital Rikshospitalet, Oslo, Norway Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
J. Røislien
Affiliation:
Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
N. Voldner
Affiliation:
Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway
K. Godang
Affiliation:
Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital Rikshospitalet, Oslo, Norway
T. Ueland
Affiliation:
Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital Rikshospitalet, Oslo, Norway Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
J. Bollerslev
Affiliation:
Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital Rikshospitalet, Oslo, Norway Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
M. B. Veierød
Affiliation:
Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
T. Henriksen
Affiliation:
Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
*
*Address for correspondence: C. M. Friis, Division of Obstetrics and Gynaecology, National Resource Centre for Women’s Health, Oslo University Hospital Rikshospitalet, Oslo, Norway. (Email [email protected])
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Abstract

The biological mechanisms in the association between maternal body mass index (BMI) and birth weight are not well understood, but are likely to involve maternal plasma glucose levels and nutrient transport across the placenta, both important modulators of fetal growth. Adipose tissue contributes to circulating levels of interleukins that may affect glucose metabolism and possibly also placental transport of nutrients. We investigated possible mediating roles of Interleukin 6 (IL-6) and Interleukin 1 Receptor antagonist (IL-1Ra) in 208 pregnant women. Known and hypothesized dependencies between BMI in early pregnancy and fasting glucose, IL-1Ra and IL-6 at gestational weeks 30–32, and birth weight were specified in a path diagram. Standardized regression coefficients, expressing direct, indirect and total effects, were estimated by Bayesian path analysis. Mean (s.d.) BMI was 24.9 kg/m2 (4.2) and mean (s.d.) birth weight 3748 g (454). The total effect of BMI on birth weight was 0.24 (95% credibility interval (CrI) [0.12, 0.36]). The direct effect of IL-1Ra on birth weight was not statistically significant, but significant effects of BMI on IL-1Ra (0.61, 95% CrI [0.51, 0.72]), of IL-1Ra on fasting glucose (0.17, 95% CrI [0.01, 0.34]) and of fasting glucose on birth weight (0.14, 95% CrI [0.01, 0.27]) implied an indirect pathway from BMI via IL-1Ra on birth weight. Approximately 20% of the effect of BMI on birth weight was mediated through IL-1Ra. For IL-6, no such effects were found. Our results indicate that IL-1Ra may be a mediator in the association between BMI and birth weight.

Keywords

birth weightBMIinflammationpath analysispregnancy
Type
Original Articles
Information
Journal of Developmental Origins of Health and Disease , Volume 1 , Issue 5 , October 2010 , pp. 310 - 318
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2010

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Footnotes

†

Joint first authors

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