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Impact of maternal hyperlipidic hypercholesterolaemic diet on male reproductive organs and testosterone concentration in rabbits

Published online by Cambridge University Press:  03 March 2014

C. Dupont ,
D. Ralliard-Rousseau ,
A. Tarrade ,
C. Faure ,
M. Dahirel ,
B. Sion ,
F. Brugnon ,
R. Levy  and
P. Chavatte-Palmer Open the ORCID record for P. Chavatte-Palmer [Opens in a new window]
C. Dupont
Affiliation:
INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France ENVA, Maisons Alfort, France APHP, Hosp Jean-Verdier, Bondy, France Université Paris 13, Sorbonne Paris Cité, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Bobigny, France
D. Ralliard-Rousseau
Affiliation:
INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France ENVA, Maisons Alfort, France
A. Tarrade
Affiliation:
INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France ENVA, Maisons Alfort, France PremUp, 4 av. de l’Observatoire, Paris, France
C. Faure
Affiliation:
APHP, Hosp Jean-Verdier, Bondy, France Université Paris 13, Sorbonne Paris Cité, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Bobigny, France
M. Dahirel
Affiliation:
INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France ENVA, Maisons Alfort, France PremUp, 4 av. de l’Observatoire, Paris, France
B. Sion
Affiliation:
Clermont Université, Université d’Auvergne, Pharmacologie Fondamentale et Clinique de la Douleur, Clermont-Ferrand, France INSERM, NEURO-DOL, Clermont-Ferrand, France
F. Brugnon
Affiliation:
CHU Clermont Ferrand, CHU Estaing, Assistance Médicale à la Procréation, CECOS, Place Aubrac, Clermont Ferrand, France Université d’Auvergne, Génétique Reproduction et Développement, Place Henri Dunant, Clermont FerrandFrance
R. Levy
Affiliation:
APHP, Hosp Jean-Verdier, Bondy, France Université Paris 13, Sorbonne Paris Cité, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Bobigny, France
P. Chavatte-Palmer*
Affiliation:
INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France ENVA, Maisons Alfort, France PremUp, 4 av. de l’Observatoire, Paris, France
*
*Address for correspondence: P. Chavatte-Palmer, UMR1198 Biologie du Développement et Reproduction, F-78350 Jouy-en Josas, France. (Email [email protected])
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Abstract

The concept of Developmental Origins of Health and Disease initially stemmed from the developmental programming of metabolic diseases. Reproductive functions and fertility in adulthood may also be programmed during foetal development. We studied the impact of dietary-induced maternal hyperlipidaemia and hypercholesterolaemia (HH), administered at 10 weeks of age and throughout the gestation and lactation, on male reproductive functions of rabbit offspring. Male rabbits born to HH dams and fed a control diet had significantly lighter testes and epididymes compared with rabbits born to control dams at adulthood. No significant changes in sperm concentration, sperm DNA integrity and sperm membrane composition were observed, but serum-free testosterone concentrations were decreased in HH males. This study confirms the importance of maternal metabolic status for the development of male reproductive organs.

Keywords

DOHADfoetal programmingmale reproductive functionmaternal dietmaternal hyperlipidaemia and hypercholesterolaemiarabbit
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 5 , Issue 3 , June 2014 , pp. 183 - 188
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

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