Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-15T01:27:01.772Z Has data issue: false hasContentIssue false
  • English
  • Français

Exposure to placental insufficiency alters postnatal growth trajectory in extremely low birth weight infants

Published online by Cambridge University Press:  04 October 2019

Fu-Sheng Chou Open the ORCID record for Fu-Sheng Chou [Opens in a new window] ,
Hung-Wen Yeh ,
Chu-Yen Chen ,
Gene T. Lee ,
Marc R. Parrish ,
Mmeyeneabasi Omede  and
Vishal Pandey
Fu-Sheng Chou
Affiliation:
Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS, USA Division of Neonatology, Children’s Mercy Kansas City, Kansas City, MO, USA
Hung-Wen Yeh
Affiliation:
Division of Health services and Outcomes Research, Children’s Mercy Kansas City, Kansas City, MO, USA
Chu-Yen Chen
Affiliation:
Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS, USA
Gene T. Lee
Affiliation:
Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, USA
Marc R. Parrish
Affiliation:
Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, USA
Mmeyeneabasi Omede
Affiliation:
Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS, USA
Vishal Pandey*
Affiliation:
Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS, USA Division of Neonatology, Children’s Mercy Kansas City, Kansas City, MO, USA
*
Address for correspondence: Vishal Pandey, Department of Pediatrics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA. Email: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Growth in the immediate postnatal period for extremely low birth weight (ELBW, birth weight < 1000 g) infants is an important topic in neonatal medicine. The goal is to ensure adequate postnatal growth and to minimize complications resulting from suboptimal growth. Past efforts have focused on postnatal nutrition as well as on minimizing comorbidities. It has not been systematically assessed whether antenatal factors play a role in postnatal growth. In this report, we conducted a retrospective study on 91 maternal–neonatal pairs. We prospectively collected maternal and neonatal demographic data, neonatal nutrition in the first 7 days of life and after enteral nutrition is fully established, comorbidity data, as well as weight data from birth to 50 weeks corrected gestational age. We developed a linear mixed-effects model to examine the role of placental insufficiency, as defined by fetal Doppler studies, in postnatal weight z-score trajectory over time in the ELBW population. We relied on Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC) for model selection. Interestingly, the selected model included a quadratic term of time and a placental insufficiency-by-time interaction term. In a covariate analysis, AIC and BIC both favored a model that included calories intake in the first 7 days of life and the total duration of antibiotics as fixed-effects, but not their interaction terms with time. Overall, we demonstrated for the first time that placental insufficiency, an antenatal factor, is a major determinant of postnatal weight trajectory in the ELBW population. Prospective studies are warranted to confirm our findings.

Keywords

Postnatal growthplacental insufficiencyextremely low birth weightpremature infant
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 4 , August 2020 , pp. 384 - 391
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Academy of Pediatrics. Committee on nutrition. Nutritional needs of low-birth-weight infants. Pediatrics. 1977; 60, 519–530.Google Scholar
Moltu, SJ, Blakstad, EW, Strømmen, K, et al.Enhanced feeding and diminished postnatal growth failure in very-low-birth-weight infants. J Pediatr Gastroenterol Nutr. 2014; 58, 344–351.10.1097/MPG.0000000000000220CrossRefGoogle ScholarPubMed
Horbar, JD, Ehrenkranz, RA, Badger, GJ, et al.Weight growth velocity and postnatal growth failure in infants 501 to 1500 grams: 2000–2013. Pediatrics. 2015; 136, e84–e92.CrossRefGoogle ScholarPubMed
Stephens, BE, Walden, RV, Gargus, RA, et al.First-week protein and energy intakes are associated with 18-month developmental outcomes in extremely low birth weight infants. Pediatrics. 2009; 123, 1337–1343.CrossRefGoogle ScholarPubMed
Guevara-Aguirre, J, Guevara-Aguirre, M, Hwa, V, et al.Intrauterine and postnatal growth failure with normal GH/IGF1 axis and insulin-resistant diabetes in a consanguineous kinship. Eur J Endocrinol/Eur Federation Endocr Soc. 2012; 166, 521–529.10.1530/EJE-11-0769CrossRefGoogle Scholar
Repa, A, Lochmann, R, Unterasinger, L, Weber, M, Berger, A, Haiden, N. Aggressive nutrition in extremely low birth weight infants: impact on parenteral nutrition associated cholestasis and growth. Peer J. 2016; 4, e2483.CrossRefGoogle Scholar
Picaud, J-C, Houeto, N, Buffin, R, Loys, C-M, Godbert, I, Haÿs, S. Additional protein fortification is necessary in extremely low-birth-weight infants fed human milk. J Pediatr Gastroenterol Nutr. 2016; 63, 103–105.10.1097/MPG.0000000000001142CrossRefGoogle ScholarPubMed
Blakstad, EW, Moltu, SJ, Nakstad, B, et al.Enhanced nutrition improves growth and increases blood adiponectin concentrations in very low birth weight infants. Food Nutr Res. 2016; 60, 33171.CrossRefGoogle ScholarPubMed
Stevens, TP, Shields, E, Campbell, D, et al.Statewide initiative to reduce postnatal growth restriction among infants <31 weeks of gestation. J Pediatr. 2018; 197, 82.e2–89.e2.CrossRefGoogle ScholarPubMed
Mariani, E, Biasini, A, Marvulli, L, et al.Strategies of increased protein intake in ELBW infants fed by human milk lead to long term benefits. Front Public Health. 2018; 6, 272.10.3389/fpubh.2018.00272CrossRefGoogle ScholarPubMed
Ehrenkranz, RA, Dusick, AM, Vohr, BR, Wright, LL, Wrage, LA, Poole, WK. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants. Pediatrics. 2006; 117, 1253–1261.CrossRefGoogle ScholarPubMed
Franz, AR, Pohlandt, F, Bode, H, et al.Intrauterine, early neonatal, and postdischarge growth and neurodevelopmental outcome at 5.4 years in extremely preterm infants after intensive neonatal nutritional support. Pediatrics. 2009; 123, e101–e109.10.1542/peds.2008-1352CrossRefGoogle ScholarPubMed
Weisglas-Kuperus, N, Hille, ETM, Duivenvoorden, HJ, et al.Intelligence of very preterm or very low birthweight infants in young adulthood. Arch Dis Childhood Fetal Neonatal Ed. 2009; 94, F196–F200.CrossRefGoogle ScholarPubMed
Zozaya, C, Díaz, C, Saenz de Pipaón, M. How should we define postnatal growth restriction in preterm infants? Neonatology. 2018; 114, 177–180.CrossRefGoogle ScholarPubMed
Griffin, IJ, Tancredi, DJ, Bertino, E, Lee, HC, Profit, J. Postnatal growth failure in very low birthweight infants born between 2005 and 2012. Arch Dis Childhood Fetal Neonatal Ed. 2016; 101, F50–F55.CrossRefGoogle ScholarPubMed
Clark, RH, Chace, DH, Spitzer, AR, Pediatrix Amino Acid Study Group. Effects of two different doses of amino acid supplementation on growth and blood amino acid levels in premature neonates admitted to the neonatal intensive care unit: a randomized, controlled trial. Pediatrics. 2007; 120, 1286–1296.CrossRefGoogle ScholarPubMed
Tan, MJ, Cooke, RW. Improving head growth in very preterm infants--a randomised controlled trial I: neonatal outcomes. Arch Dis Childhood-Fetal Neonatal Ed. 2008; 93, F337–F341.CrossRefGoogle ScholarPubMed
Burattini, I, Bellagamba, MP, Spagnoli, C, et al.Targeting 2.5 versus 4 g/kg/day of amino acids for extremely low birth weight infants: a randomized clinical trial. J Pediatr. 2013; 163, 1278.e1–1282.e1.10.1016/j.jpeds.2013.06.075CrossRefGoogle ScholarPubMed
Bellagamba, MP, Carmenati, E, D’Ascenzo, R, et al.One extra gram of protein to preterm infants from birth to 1800 g: a single-blinded randomized clinical trial. J Pediatr Gastroenterol Nutr. 2016; 62, 879–884.CrossRefGoogle Scholar
Bartholomew, J, Martin, CR, Allred, E, et al.Risk factors and correlates of neonatal growth velocity in extremely low gestational age newborns: the ELGAN Study. Neonatology. 2013; 104, 298–304.CrossRefGoogle ScholarPubMed
Lee, SM, Kim, N, Namgung, R, Park, M, Park, K, Jeon, J. Prediction of postnatal growth Failure among very low birth weight infants. Sci Rep. 2018; 8, 3729.10.1038/s41598-018-21647-9CrossRefGoogle ScholarPubMed
Sharma, D, Shastri, S, Sharma, P. Intrauterine growth restriction: antenatal and postnatal aspects. Clin Med Insights Pediatr. 2016; 10, 67–83.10.4137/CMPed.S40070CrossRefGoogle ScholarPubMed
Murphy, SN, Weber, G, Mendis, M, et al.Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). J Am Med Inf Assoc. 2010; 17, 124–130.10.1136/jamia.2009.000893CrossRefGoogle Scholar
Waitman, LR, Warren, JJ, Manos, EL, Connolly, DW. Expressing observations from electronic medical record flowsheets in an i2b2 based clinical data repository to support research and quality improvement. In AMIA … Annual Symposium proceedings/AMIA Symposium. AMIA Symposium. 2011; pp. 1454–1463. Washington, DC, USA.Google Scholar
Unterscheider, J, Daly, S, Geary, MP, et al.Optimizing the definition of intrauterine growth restriction: the multicenter prospective PORTO Study. Am J Obstetr Gynecol. 2013; 208, 290.e1–296.e1.CrossRefGoogle ScholarPubMed
Fenton, TR, Nasser, R, Eliasziw, M, Kim, JH, Bilan, D, Sauve, R. Validating the weight gain of preterm infants between the reference growth curve of the fetus and the term infant. BMC Pediatr. 2013; 13, 92.CrossRefGoogle ScholarPubMed
RStudio. RStudio (n.d.). http://www.rstudio.com (accessed May 20, 2019).Google Scholar
Ripley, BD. The R project in statistical computing. MSOR Connections. Newsl LTSN Maths Stats OR Network. 2001; 1, 23–25.Google Scholar
Torchiano, M. Effsize – a package for efficient effect size computation. 2016. https://doi.org/10.5281/zenodo.1480624.CrossRefGoogle Scholar
CRAN - Package PropCIs. (n.d.). https://CRAN.R-project.org/package=PropCIs (accessed April 14, 2019).Google Scholar
Bates, D, Mächler, M, Bolker, B, Walker, S. Fitting linear mixed-effects models using lme4. J Stat Softw Articles. 2015; 67, 1–48.Google Scholar
Kuznetsova, A, Brockhoff, P, Christensen, R. lmerTest package: tests in linear mixed effects models. J Stat Softw Articles. 2017; 82, 1–26.Google Scholar
Lüdecke, D. sjPlot - Data Visualization for Statistics in Social Science (Zenodo, 2018). https://doi.org/10.5281/ZENODO.1308157.CrossRefGoogle Scholar
Rochow, N, Raja, P, Liu, K, et al.Physiological adjustment to postnatal growth trajectories in healthy preterm infants. Pediatr Res. 2016; 79, 870–879.10.1038/pr.2016.15CrossRefGoogle ScholarPubMed
Baschat, AA. Fetal responses to placental insufficiency: an update. BJOG Int J Obstetr Gynaecol. 2004; 111, 1031–1041.10.1111/j.1471-0528.2004.00273.xCrossRefGoogle ScholarPubMed
Longtine, MS, Nelson, DM. Placental dysfunction and fetal programming: the importance of placental size, shape, histopathology, and molecular composition. Semin Reprod Med. 2011; 29, 187–196.CrossRefGoogle ScholarPubMed
Longo, S, Bollani, L, Decembrino, L, Comite, AD, Angelini, M, Stronati, M. Short-term and long-term sequelae in intrauterine growth retardation (IUGR). J Maternal-Fetal Neonatal Med. 2012; 26, 1–4.Google Scholar
Hoyer, D, Tetschke, F, Jaekel, S, et al.Fetal functional brain age assessed from universal developmental indices obtained from neuro-vegetative activity patterns. PloS one. 2013; 8, e74431.10.1371/journal.pone.0074431CrossRefGoogle ScholarPubMed
Barker, DJ, Osmond, C. Low birth weight and hypertension. BMJ. 1988; 297, 134–135.CrossRefGoogle ScholarPubMed
Warshafsky, C, Pudwell, J, Walker, M, Wen, S-W, Smith, GN, Preeclampsia New Emerging Team. Prospective assessment of neurodevelopment in children following a pregnancy complicated by severe pre-eclampsia. BMJ Open. 2016; 6, e010884.10.1136/bmjopen-2015-010884CrossRefGoogle ScholarPubMed
Rodríguez-Rodríguez, P, Ramiro-Cortijo, D, Reyes-Hernández, CG, López de Pablo, AL, González, MC, Arribas, SM. Implication of oxidative stress in fetal programming of cardiovascular disease. Front Physiol. 2018; 9, 602.10.3389/fphys.2018.00602CrossRefGoogle ScholarPubMed
Brown, LD, Hay, WW Jr. Impact of placental insufficiency on fetal skeletal muscle growth. Mol cell Endocrinol. 2016; 435, 69–77.CrossRefGoogle ScholarPubMed
Mohan, R, Baumann, D, Alejandro, EU. Fetal undernutrition, placental insufficiency, and pancreatic β-cell development programming in utero. Am J Physiol Regul Integr Comp Physiol. 2018; 315, R867–R878.10.1152/ajpregu.00072.2018CrossRefGoogle ScholarPubMed
Wang, J, Chen, L, Li, D, et al.Intrauterine growth restriction affects the proteomes of the small intestine, liver, and skeletal muscle in newborn pigs. J Nutr. 2008; 138, 60–66.CrossRefGoogle ScholarPubMed
D’Inca, R, Gras-Le Guen, C, Che, L, Sangild, PT, Le Huërou-Luron, I. Intrauterine growth restriction delays feeding-induced gut adaptation in term newborn pigs. Neonatology. 2011; 99, 208–216.CrossRefGoogle ScholarPubMed
Wang, W, Degroote, J, Van Ginneken, C, et al.Intrauterine growth restriction in neonatal piglets affects small intestinal mucosal permeability and mRNA expression of redox-sensitive genes. FASEB J. 2016; 30, 863–873.CrossRefGoogle ScholarPubMed
Cooke, RJ. Catch-up growth: implications for the preterm and term infant. Eur J Clin Nutr. 2010; 64(Suppl 1), S8–S10.CrossRefGoogle ScholarPubMed
Claas, MJ, de Vries, LS, Koopman, C, et al.Postnatal growth of preterm born children ≤750g at birth. Early Hum Dev. 2011; 87, 495–507. doi:10.1016/j.earlhumdev.2011.04.009.CrossRefGoogle ScholarPubMed
Ramel, SE, Gray, HL, Ode, KL, Younge, N, Georgieff, MK, Demerath, EW. Body composition changes in preterm infants following hospital discharge: comparison with term infants. J Pediatr Gastroenterol Nutr. 2011; 53, 333–338.CrossRefGoogle ScholarPubMed
Johnson, MJ, Wootton, SA, Leaf, AA, Jackson, AA. Preterm birth and body composition at term equivalent age: a systematic review and meta-analysis. Pediatrics. 2012; 130, e640–e649.CrossRefGoogle ScholarPubMed
Simon, L, Borrego, P, Darmaun, D, Legrand, A, Rozé, J-C, Chauty-Frondas, A. Effect of sex and gestational age on neonatal body composition. Br J Nutr. 2013; 109, 1105–1108.CrossRefGoogle ScholarPubMed
Bardien, N, Whitehead, CL, Tong, S, Ugoni, A, McDonald, S, Walker, SP. Placental insufficiency in fetuses that slow in growth but are born appropriate for gestational age: a prospective longitudinal study. PloS one. 2016; 11, e0142788.CrossRefGoogle Scholar
Supplementary material: File

Chou et al. supplementary material

Chou et al. supplementary material

Download Chou et al. supplementary material(File)
File 7.5 MB